دورية أكاديمية
Associating transcription factors to single-cell trajectories with DREAMIT
| العنوان: | Associating transcription factors to single-cell trajectories with DREAMIT |
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| المؤلفون: | Nathan D. Maulding, Lucas Seninge, Joshua M. Stuart |
| المصدر: | Genome Biology, Vol 25, Iss 1, Pp 1-21 (2024) |
| بيانات النشر: | BMC, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Biology (General) LCC:Genetics |
| مصطلحات موضوعية: | Biology (General), QH301-705.5, Genetics, QH426-470 |
| الوصف: | Abstract Inferring gene regulatory networks from single-cell RNA-sequencing trajectories has been an active area of research yet methods are still needed to identify regulators governing cell transitions. We developed DREAMIT (Dynamic Regulation of Expression Across Modules in Inferred Trajectories) to annotate transcription-factor activity along single-cell trajectory branches, using ensembles of relations to target genes. Using a benchmark representing several different tissues, as well as external validation with ATAC-Seq and Perturb-Seq data on hematopoietic cells, the method was found to have higher tissue-specific sensitivity and specificity over competing approaches. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1474-760X |
| Relation: | https://doaj.org/toc/1474-760X |
| DOI: | 10.1186/s13059-024-03368-7 |
| URL الوصول: | https://doaj.org/article/c61dfb181b57437ebce32fd3a8d7dcec |
| رقم الأكسشن: | edsdoj.61dfb181b57437ebce32fd3a8d7dcec |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1474760X |
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| DOI: | 10.1186/s13059-024-03368-7 |