The glycosylation design space for recombinant lysosomal replacement enzymes produced in CHO cells

التفاصيل البيبلوغرافية
العنوان:	The glycosylation design space for recombinant lysosomal replacement enzymes produced in CHO cells
المؤلفون:	Weihua Tian, Zilu Ye, Shengjun Wang, Morten Alder Schulz, Julie Van Coillie, Lingbo Sun, Yen-Hsi Chen, Yoshiki Narimatsu, Lars Hansen, Claus Kristensen, Ulla Mandel, Eric Paul Bennett, Siamak Jabbarzadeh-Tabrizi, Raphael Schiffmann, Jin-Song Shen, Sergey Y. Vakhrushev, Henrik Clausen, Zhang Yang
المصدر:	Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
بيانات النشر:	Nature Portfolio, 2019.
سنة النشر:	2019
المجموعة:	LCC:Science
مصطلحات موضوعية:	Science
الوصف:	Lysosomal replacement enzymes are taken up by cell surface receptors that recognize glycans, the effects of different glycan features are unknown. Here the authors present a gene engineering screen in CHO cells that allows custom N-glycan-decorated enzymes with improved circulation time and organ distribution.
نوع الوثيقة:	article
وصف الملف:	electronic resource
اللغة:	English
تدمد:	2041-1723
Relation:	https://doaj.org/toc/2041-1723
DOI:	10.1038/s41467-019-09809-3
URL الوصول:	https://doaj.org/article/61e178a4b78e40d9866c7f7e1c00ad4a
رقم الأكسشن:	edsdoj.61e178a4b78e40d9866c7f7e1c00ad4a
قاعدة البيانات:	Directory of Open Access Journals

الوصف
تدمد:	20411723
DOI:	10.1038/s41467-019-09809-3