دورية أكاديمية
Nephrotoxicity Biomarkers: Role and Significance in the Diagnosis of Drug-Induced Kidney Injury
| العنوان: | Nephrotoxicity Biomarkers: Role and Significance in the Diagnosis of Drug-Induced Kidney Injury |
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| المؤلفون: | O. V. Muslimova, V. A. Evteev, I. A. Mazerkina, E. A. Sokova, A. B. Prokofiev, A. V. Shapchenko, T. V. Alexandrova |
| المصدر: | Безопасность и риск фармакотерапии, Vol 9, Iss 4, Pp 173-184 (2021) |
| بيانات النشر: | Ministry of Health of the Russian Federation, Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products», 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Therapeutics. Pharmacology |
| مصطلحات موضوعية: | biomarkers, drug nephrotoxicity, acute kidney injury, nag, l-fabp, kim-1, ngal, β2-microglobulin, mcp-1, cystatin c, igfbp7, timp-2, Therapeutics. Pharmacology, RM1-950 |
| الوصف: | Drug-induced kidney injury (DIKI) accounts for 8 to 60% of episodes of acute kidney injury (AKI) among hospital patients. Early DIKI detection and timely adjustment of therapy will help reduce the kidney injury incidence and mortality. The aim of the study was to analyse scientific literature on the biomarkers used in DIKI diagnosis. The study revealed that the use of such kidney damage markers as serum creatinine, urinary output, urea nitrogen, sodium excretion, urinary sediment microscopy is limited because they do not give a full picture of the kidney injury degree and progression and do not allow for early AKI diagnosis. It was demonstrated that some of the most promising biomarkers are KIM-1, L-FABP, NAG, NGAL, cystatin C, clusterin, β2-microglobulin, МСР-1, IGFBP7, and TIMP-2. However, recommendations for determination of these biomarkers’ urine or blood concentrations for AKI diagnosis are somewhat preliminary, because there have been insufficient clinical and preclinical studies to establish validity of such tests. No precise algorithms based on determination of the biomarkers levels in urea and/or blood serum have been developed for AKI risk assessment, diagnosis, monitoring, and treatment. Thus, further research is necessary to investigate different AKI biomarkers and improve experimental models (both in vivo and in vitro), which will support assessment of potential nephrotoxic properties of existing and new medicinal products. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | Russian |
| تدمد: | 2312-7821 2619-1164 |
| Relation: | https://www.risksafety.ru/jour/article/view/238; https://doaj.org/toc/2312-7821; https://doaj.org/toc/2619-1164 |
| DOI: | 10.30895/2312-7821-2021-9-4-173-184 |
| URL الوصول: | https://doaj.org/article/61ef441fa7c147e8b087565c53b1f2c7 |
| رقم الأكسشن: | edsdoj.61ef441fa7c147e8b087565c53b1f2c7 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23127821 26191164 |
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| DOI: | 10.30895/2312-7821-2021-9-4-173-184 |