Deep multiomics profiling of brain tumors identifies signaling networks downstream of cancer driver genes

التفاصيل البيبلوغرافية
العنوان:	Deep multiomics profiling of brain tumors identifies signaling networks downstream of cancer driver genes
المؤلفون:	Hong Wang, Alexander K. Diaz, Timothy I. Shaw, Yuxin Li, Mingming Niu, Ji-Hoon Cho, Barbara S. Paugh, Yang Zhang, Jeffrey Sifford, Bing Bai, Zhiping Wu, Haiyan Tan, Suiping Zhou, Laura D. Hover, Heather S. Tillman, Abbas Shirinifard, Suresh Thiagarajan, Andras Sablauer, Vishwajeeth Pagala, Anthony A. High, Xusheng Wang, Chunliang Li, Suzanne J. Baker, Junmin Peng
المصدر:	Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
بيانات النشر:	Nature Portfolio, 2019.
سنة النشر:	2019
المجموعة:	LCC:Science
مصطلحات موضوعية:	Science
الوصف:	Multi-omic profiling is a powerful approach to dissecting molecular mechanisms in disease. Here the authors generate whole proteome, phosphoproteome and transcriptome profiles from two mouse models of high-grade glioma driven by different oncogenes, and validate identified master regulators with a CRISPR screen.
نوع الوثيقة:	article
وصف الملف:	electronic resource
اللغة:	English
تدمد:	2041-1723
Relation:	https://doaj.org/toc/2041-1723
DOI:	10.1038/s41467-019-11661-4
URL الوصول:	https://doaj.org/article/61f32b7ce86246f7a09c004f13127043
رقم الأكسشن:	edsdoj.61f32b7ce86246f7a09c004f13127043
قاعدة البيانات:	Directory of Open Access Journals

الوصف
تدمد:	20411723
DOI:	10.1038/s41467-019-11661-4