The artificial Lake Buyo is an important water reservoir that ensures the availability of water for multiple purposes: drinking water supply, fishing, and energy. In the last five years, this lake has experienced extreme variations in its surface area and water levels, including very significant declines, which has impacted the supply of electricity. This study aimed to assess temporal variations in the water levels of Lake Buyo using radar altimetry. Altimetric data from the Sentinel-3A satellite on Lake Buyo (tracks 16 (orbit 8) and 743 (orbit 372)) were selected over the period from 31 May 2016 to 12 June 2021 and compared to the in situ measurements provided by the Direction de la Production de l’Electricité de Côte d’Ivoire (DPE-CI). The extraction of the time series of the Sentinel-3A altimetric water levels and their corrections (geophysical and environmental corrections) were carried out with the ALTiS software. The results showed an overall agreement between the altimetric water levels and the in situ measurements, with a correlation coefficient (R2) ranging from 0.98 to 0.99 obtained, as well as a Nash–Sutcliffe Efficiency (NSE) coefficient also between 0.98 and 0.99. Further, the bias (0.12 m and 0.13 m) and root mean square error (RMSE) (0.38 and 0.67 m) values showed that the results were acceptable. The analysis of the water levels time series allowed for the identification of two main periods: March to October and November to February. The first period corresponded to a high level period, recording a maximum level of 200.06 m. The second period, from November to March, was characterized by a drop in the water level, recording a minimum level of 187.42 m. The water levels time series provided by Sentinel-3 allowed us to appreciate the respective influences of seasonal and interannual variations on rainfall and the contributions of the Sassandra River tributaries to the water levels of Lake Buyo.