دورية أكاديمية
Trial design: The effect of high-dose rosuvastatin on echocardiographic parameters in patients with intermediate- and high-risk pulmonary embolism – A randomized placebo-controlled trial
| العنوان: | Trial design: The effect of high-dose rosuvastatin on echocardiographic parameters in patients with intermediate- and high-risk pulmonary embolism – A randomized placebo-controlled trial |
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| المؤلفون: | Azin Alizadeh Asl, Mohamad Mehdi Peighambari, Jamal Moosavi, Omid Shafe, Moona Naghshbandi, Melody Farrashi, Nakisa Khansary, Hamid Reza Pouraliakbar, Kiara Rezaei Kalantari, Hooman Bakhshandeh, Hamed Talakoob, Maryam Mohseni Salehi, Sajjad Naderi, Ehsan Ghourchian, Farzaneh Mehrvarz, Nahid Rafiee, Parham Sadeghipour |
| المصدر: | Research in Cardiovascular Medicine, Vol 8, Iss 1, Pp 29-34 (2019) |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Diseases of the circulatory (Cardiovascular) system |
| مصطلحات موضوعية: | Echocardiography, high-intensity statin, pulmonary embolism, right ventricular function, rosuvastatin, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| الوصف: | Background: It has been shown recently that a considerable burden of pulmonary embolism (PE) roots from an inflammatory response. The activated inflammatory cascade will be responsible for the final fibrotic response of pulmonary vascular bed, creating further mechanical obstruction which results in subsequent right ventricular (RV) dysfunction, influencing functional capacity and future prognosis. Although anticoagulants represent the cornerstone treatment of PE, the drug class has a minimal effect on the mentioned pathology. Study Design: The present study is a single-center randomized, double-blind, parallel group controlled trial with placebo which will evaluate the effect of high-intensity statin – rosuvastatin 20 mg daily on patients with intermediate-to-high-risk PE. Study population will be selected from patients for whom statin is not otherwise indicated. Primary end point of the present trial will be echocardiographic measures of RV function. We believe that the mentioned indexes represent an accurate surrogate for the functional capacity and prognosis. Our secondary end point will be the composites of PE recurrence and exertional capacity measured by 6-minute walk test. Conclusions: The result of the present trial might influence the complimentary treatment of acute PE. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2251-9572 2251-9580 |
| Relation: | http://www.rcvmonline.com/article.asp?issn=2251-9572;year=2019;volume=8;issue=1;spage=29;epage=34;aulast=Asl; https://doaj.org/toc/2251-9572; https://doaj.org/toc/2251-9580 |
| DOI: | 10.4103/rcm.rcm_3_19 |
| URL الوصول: | https://doaj.org/article/622613a306dc4b19b957937d51b0bf01 |
| رقم الأكسشن: | edsdoj.622613a306dc4b19b957937d51b0bf01 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22519572 22519580 |
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| DOI: | 10.4103/rcm.rcm_3_19 |