دورية أكاديمية

Long-Smoldering T-prolymphocytic Leukemia: A Case Report and a Review of the Literature

التفاصيل البيبلوغرافية
العنوان: Long-Smoldering T-prolymphocytic Leukemia: A Case Report and a Review of the Literature
المؤلفون: Hilde K. Gjelberg, Lars Helgeland, Knut Liseth, Francesca Micci, Miriam Sandnes, Hege G. Russnes, Håkon Reikvam
المصدر: Current Oncology, Vol 30, Iss 11, Pp 10007-10018 (2023)
بيانات النشر: MDPI AG, 2023.
سنة النشر: 2023
المجموعة: LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
مصطلحات موضوعية: T-prolymphocytic leukemia (T-PLL), TCL1, ATM, JAK/STAT, alemtuzumab, pentostatin, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
الوصف: T-prolymphocytic leukemia (T-PLL) is a rare malignancy of mature T-cells with distinct clinical, cytomorphological, and molecular genetic features. The disease typically presents at an advanced stage, with marked leukocytosis, B symptoms, hepatosplenomegaly, and bone marrow failure. It usually follows an aggressive course from presentation, and the prognosis is often considered dismal; the median overall survival is less than one year with conventional chemotherapy. This case report describes a patient with T-PLL who, after an unusually protracted inactive phase, ultimately progressed to a highly invasive, organ-involving disease. After initial treatments failed, a novel treatment approach resulted in a significant response.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1718-7729
1198-0052
Relation: https://www.mdpi.com/1718-7729/30/11/727; https://doaj.org/toc/1198-0052; https://doaj.org/toc/1718-7729
DOI: 10.3390/curroncol30110727
URL الوصول: https://doaj.org/article/6248a833b81a4966a9b67e5e2a9ad5e7
رقم الأكسشن: edsdoj.6248a833b81a4966a9b67e5e2a9ad5e7
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:17187729
11980052
DOI:10.3390/curroncol30110727