دورية أكاديمية
Long-Smoldering T-prolymphocytic Leukemia: A Case Report and a Review of the Literature
العنوان: | Long-Smoldering T-prolymphocytic Leukemia: A Case Report and a Review of the Literature |
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المؤلفون: | Hilde K. Gjelberg, Lars Helgeland, Knut Liseth, Francesca Micci, Miriam Sandnes, Hege G. Russnes, Håkon Reikvam |
المصدر: | Current Oncology, Vol 30, Iss 11, Pp 10007-10018 (2023) |
بيانات النشر: | MDPI AG, 2023. |
سنة النشر: | 2023 |
المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
مصطلحات موضوعية: | T-prolymphocytic leukemia (T-PLL), TCL1, ATM, JAK/STAT, alemtuzumab, pentostatin, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
الوصف: | T-prolymphocytic leukemia (T-PLL) is a rare malignancy of mature T-cells with distinct clinical, cytomorphological, and molecular genetic features. The disease typically presents at an advanced stage, with marked leukocytosis, B symptoms, hepatosplenomegaly, and bone marrow failure. It usually follows an aggressive course from presentation, and the prognosis is often considered dismal; the median overall survival is less than one year with conventional chemotherapy. This case report describes a patient with T-PLL who, after an unusually protracted inactive phase, ultimately progressed to a highly invasive, organ-involving disease. After initial treatments failed, a novel treatment approach resulted in a significant response. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1718-7729 1198-0052 |
Relation: | https://www.mdpi.com/1718-7729/30/11/727; https://doaj.org/toc/1198-0052; https://doaj.org/toc/1718-7729 |
DOI: | 10.3390/curroncol30110727 |
URL الوصول: | https://doaj.org/article/6248a833b81a4966a9b67e5e2a9ad5e7 |
رقم الأكسشن: | edsdoj.6248a833b81a4966a9b67e5e2a9ad5e7 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 17187729 11980052 |
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DOI: | 10.3390/curroncol30110727 |