دورية أكاديمية
Volatile organic compound profiling to explore primary graft dysfunction after lung transplantation
| العنوان: | Volatile organic compound profiling to explore primary graft dysfunction after lung transplantation |
|---|---|
| المؤلفون: | Pierre-Hugues Stefanuto, Rosalba Romano, Christiaan A. Rees, Mavra Nasir, Louit Thakuria, Andre Simon, Anna K. Reed, Nandor Marczin, Jane E. Hill |
| المصدر: | Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022) |
| بيانات النشر: | Nature Portfolio, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | Abstract Primary graft dysfunction (PGD) is a major determinant of morbidity and mortality following lung transplantation. Delineating basic mechanisms and molecular signatures of PGD remain a fundamental challenge. This pilot study examines if the pulmonary volatile organic compound (VOC) spectrum relate to PGD and postoperative outcomes. The VOC profiles of 58 bronchoalveolar lavage fluid (BALF) and blind bronchial aspirate samples from 35 transplant patients were extracted using solid-phase-microextraction and analyzed with comprehensive two-dimensional gas chromatography coupled to time-of-flight mass spectrometry. The support vector machine algorithm was used to identify VOCs that could differentiate patients with severe from lower grade PGD. Using 20 statistically significant VOCs from the sample headspace collected immediately after transplantation ( |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-022-05994-2 |
| URL الوصول: | https://doaj.org/article/6249dd13cc044787a33167bf029d6a88 |
| رقم الأكسشن: | edsdoj.6249dd13cc044787a33167bf029d6a88 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 20452322 |
|---|---|
| DOI: | 10.1038/s41598-022-05994-2 |