دورية أكاديمية
Novel Copper(II) Complexes with N4,S-Diallylisothiosemicarbazones as Potential Antibacterial/Anticancer Drugs
| العنوان: | Novel Copper(II) Complexes with N4,S-Diallylisothiosemicarbazones as Potential Antibacterial/Anticancer Drugs |
|---|---|
| المؤلفون: | Vasilii Graur, Irina Usataia, Ianina Graur, Olga Garbuz, Paulina Bourosh, Victor Kravtsov, Carolina Lozan-Tirsu, Greta Balan, Valeriu Fala, Aurelian Gulea |
| المصدر: | Inorganics, Vol 11, Iss 5, p 195 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Inorganic chemistry |
| مصطلحات موضوعية: | isothiosemicarbazones, copper complexes, antiproliferative activity, antibacterial activity, antifungal activity, antiradical activity, Inorganic chemistry, QD146-197 |
| الوصف: | The six new copper(II) coordination compounds [Cu(HL1)Cl2] (1), [Cu(HL1)Br2] (2), [Cu(H2O)(L1)(CH3COO)]·1.75H2O (3), [Cu(HL2)Cl2] (4), [Cu(HL2)Br2] (5), [Cu(H2O)(L2)(CH3COO)] (6) were synthesized with 2-formyl- and 2-acetylpyridine N4,S-diallylisothiosemicarbazones (HL1 and HL2). The new isothiosemicarbazones were characterized by NMR, FTIR spectroscopy, and X-ray crystallography ([H2L2]I). All copper(II) coordination compounds were characterized by elemental analysis, FTIR spectroscopy, and molar conductivity of their 1mM methanol solutions. Furthermore, the crystal structure of complex 3 was determined using single-crystal X-ray diffraction analysis. The studied complexes manifest antibacterial and antifungal activities, that in many cases are close to the activity of medical drugs used in this area, and in some cases even exceed them. The complexes 4 and 5 showed the highest indexes of selectivity (280 and 154) and high antiproliferative activity against BxPC-3 cell lines that surpass the activity of Doxorubicin. The complexes 1–3 also manifest antioxidant activities against cation radicals ABTS•+ that are close to that of trolox, the antioxidant agent used in medicine. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 11050195 2304-6740 |
| Relation: | https://www.mdpi.com/2304-6740/11/5/195; https://doaj.org/toc/2304-6740 |
| DOI: | 10.3390/inorganics11050195 |
| URL الوصول: | https://doaj.org/article/6270313668094237b658bcd1a09eb52a |
| رقم الأكسشن: | edsdoj.6270313668094237b658bcd1a09eb52a |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 11050195 23046740 |
|---|---|
| DOI: | 10.3390/inorganics11050195 |