دورية أكاديمية
The First Evaluation of Proteinase K-Resistant Prion Protein (PrPSc) in Korean Appendix Specimens
| العنوان: | The First Evaluation of Proteinase K-Resistant Prion Protein (PrPSc) in Korean Appendix Specimens |
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| المؤلفون: | Sae-Young Won, Yong-Chan Kim, Yu-Ni Lee, Chan-Gyun Park, Woo-Young Kim, Byung-Hoon Jeong |
| المصدر: | Medicina, Vol 58, Iss 7, p 947 (2022) |
| بيانات النشر: | MDPI AG, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medicine (General) |
| مصطلحات موضوعية: | prion, PrPSc, Creutzfeldt–Jakob disease, variant CJD, PRNP, appendectomy, Medicine (General), R5-920 |
| الوصف: | Background and Objectives: Prion diseases are fatal neurodegenerative disorders caused by the abnormal proteinase K-resistant prion protein (PrPSc). Since variant Creutzfeldt–Jakob disease (CJD) was first reported in the United Kingdom (UK) in 1996, the occurrence of variant CJD has been reported in over 10 countries. To date, variant CJD has not been reported in Korea. However, the E211K somatic mutation in the prion protein gene (PRNP), which is related to bovine spongiform encephalopathy (BSE), was reported in Korean Holstein cattle, and atypical BSE, which is supposed to be sporadic BSE, has been occurring in many countries, including Japan and the USA. These results suggest that BSE may occur naturally in Korea. Thus, we performed a preemptive PrPSc test in appendix specimens to diagnose variant CJD in a Korean population. Materials and Methods: In the present study, we investigated CJD-related mutations and polymorphisms of the PRNP gene and carried out an examination on PrPSc in appendix specimens of Korean patients after appendectomy. Results: In all Korean appendix specimens tested, PrPSc bands were not detected. Conclusion: To the best of our knowledge, this was the first evaluation of PrPSc in Korean appendix specimens. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1648-9144 1010-660X |
| Relation: | https://www.mdpi.com/1648-9144/58/7/947; https://doaj.org/toc/1010-660X; https://doaj.org/toc/1648-9144 |
| DOI: | 10.3390/medicina58070947 |
| URL الوصول: | https://doaj.org/article/a627553515ef45558f2df11690f1eab2 |
| رقم الأكسشن: | edsdoj.627553515ef45558f2df11690f1eab2 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 16489144 1010660X |
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| DOI: | 10.3390/medicina58070947 |