دورية أكاديمية
Primary tumor consolidative therapy improves the outcomes of patients with advanced -mutant lung adenocarcinoma treated with first-line osimertinib
العنوان: | Primary tumor consolidative therapy improves the outcomes of patients with advanced -mutant lung adenocarcinoma treated with first-line osimertinib |
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المؤلفون: | Jia-Jun Wu, Jeng-Sen Tseng, Zhe-Rong Zheng, Cheng-Hsiang Chu, Kun-Chieh Chen, Mong-Wei Lin, Yen-Hsiang Huang, Kuo-Hsuan Hsu, Tsung-Ying Yang, Sung-Liang Yu, Jin-Shing Chen, Chao-Chi Ho, Gee-Chen Chang |
المصدر: | Therapeutic Advances in Medical Oncology, Vol 16 (2024) |
بيانات النشر: | SAGE Publishing, 2024. |
سنة النشر: | 2024 |
المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
مصطلحات موضوعية: | Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
الوصف: | Background: Patients with advanced epidermal growth factor receptor ( EGFR )-mutant lung adenocarcinoma (LAD) inevitably experience drug resistance following treatment with EGFR-tyrosine kinase inhibitors (TKIs). Objectives: We aimed to analyze the effect of primary tumor consolidative therapy (PTCT) on patients treated with first-line osimertinib. Design and methods: This retrospective cohort study was conducted in patients with advanced stage III or stage IV LAD with EGFR-sensitizing mutations (exon 19 deletion or L858R mutation) with disease control after first-line osimertinib. A curative dose of primary tumor radiotherapy or primary tumor resection was classified as PTCT. We compared the progression-free survival (PFS) and overall survival (OS) of patients with and without PTCT. Results: This study included 106 patients with a median age of 61.0 years, and of those, 42% were male and 73.6% were never-smokers. Exon 19 deletion was observed in 67.9%, 30.2% had a programmed cell death ligand 1 (PD-L1) tumor proportion score |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1758-8359 17588359 |
Relation: | https://doaj.org/toc/1758-8359 |
DOI: | 10.1177/17588359231220606 |
URL الوصول: | https://doaj.org/article/6317e05ebe794654ab42f2e9299df02d |
رقم الأكسشن: | edsdoj.6317e05ebe794654ab42f2e9299df02d |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 17588359 |
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DOI: | 10.1177/17588359231220606 |