دورية أكاديمية
أعرض في EDS

Primary tumor consolidative therapy improves the outcomes of patients with advanced -mutant lung adenocarcinoma treated with first-line osimertinib

التفاصيل البيبلوغرافية
العنوان: Primary tumor consolidative therapy improves the outcomes of patients with advanced -mutant lung adenocarcinoma treated with first-line osimertinib
المؤلفون: Jia-Jun Wu, Jeng-Sen Tseng, Zhe-Rong Zheng, Cheng-Hsiang Chu, Kun-Chieh Chen, Mong-Wei Lin, Yen-Hsiang Huang, Kuo-Hsuan Hsu, Tsung-Ying Yang, Sung-Liang Yu, Jin-Shing Chen, Chao-Chi Ho, Gee-Chen Chang
المصدر: Therapeutic Advances in Medical Oncology, Vol 16 (2024)
بيانات النشر: SAGE Publishing, 2024.
سنة النشر: 2024
المجموعة: LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
مصطلحات موضوعية: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
الوصف: Background: Patients with advanced epidermal growth factor receptor ( EGFR )-mutant lung adenocarcinoma (LAD) inevitably experience drug resistance following treatment with EGFR-tyrosine kinase inhibitors (TKIs). Objectives: We aimed to analyze the effect of primary tumor consolidative therapy (PTCT) on patients treated with first-line osimertinib. Design and methods: This retrospective cohort study was conducted in patients with advanced stage III or stage IV LAD with EGFR-sensitizing mutations (exon 19 deletion or L858R mutation) with disease control after first-line osimertinib. A curative dose of primary tumor radiotherapy or primary tumor resection was classified as PTCT. We compared the progression-free survival (PFS) and overall survival (OS) of patients with and without PTCT. Results: This study included 106 patients with a median age of 61.0 years, and of those, 42% were male and 73.6% were never-smokers. Exon 19 deletion was observed in 67.9%, 30.2% had a programmed cell death ligand 1 (PD-L1) tumor proportion score
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1758-8359
17588359
Relation: https://doaj.org/toc/1758-8359
DOI: 10.1177/17588359231220606
URL الوصول: https://doaj.org/article/6317e05ebe794654ab42f2e9299df02d
رقم الأكسشن: edsdoj.6317e05ebe794654ab42f2e9299df02d
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:17588359
DOI:10.1177/17588359231220606