دورية أكاديمية
Involvement of Akt/CREB signaling pathways in the protective effect of EPA against interleukin-1β-induced cytotoxicity and BDNF down-regulation in cultured rat hippocampal neurons
| العنوان: | Involvement of Akt/CREB signaling pathways in the protective effect of EPA against interleukin-1β-induced cytotoxicity and BDNF down-regulation in cultured rat hippocampal neurons |
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| المؤلفون: | YiLong Dong, KangJing Pu, WenJing Duan, HuiCheng Chen, LiXing Chen, YanMei Wang |
| المصدر: | BMC Neuroscience, Vol 19, Iss 1, Pp 1-8 (2018) |
| بيانات النشر: | BMC, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Neurosciences. Biological psychiatry. Neuropsychiatry LCC:Neurophysiology and neuropsychology |
| مصطلحات موضوعية: | Eicosapentaenoic acid, Brain-derived neurotrophic factor, Akt, Interleukin-1β, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurophysiology and neuropsychology, QP351-495 |
| الوصف: | Abstract Background Our published data have indicated that the omega-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) provides beneficial effects by attenuating neuronal damage induced by interleukin-1β (IL-1β), and up-regulation of the expression of brain-derived neurotrophic factor (BDNF) represents a crucial part in the neuroprotective effect of EPA. However, the mechanisms of how EPA regulates BDNF expression remains incompletely understood. The present study investigated the role of Akt/CREB signaling in the effect of EPA on BDNF expression and its neuroprotective effect. Results The present results showed that IL-1β reduced hippocampal neuronal viability and that EPA showed a concentration-dependent neuroprotective effect, but the neuroprotective effects of EPA were abolished by inhibition of Akt using KRX-0401, an inhibitor of Akt. Treatment of hippocampal neurons with EPA also ameliorated the decrease in Akt and CREB phosphorylation induced by IL-1β and BDNF down-regulation mediated by IL-1β. However, inhibition of Akt reversed the effect of EPA on levels of p-Akt, p-CREB, and BDNF. Conclusions Our data indicate that EPA elicited neuroprotection toward IL-1β-induced cell damage and BDNF decrease and that its effects potentially occurred via the Akt/CREB signaling pathway. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1471-2202 |
| Relation: | http://link.springer.com/article/10.1186/s12868-018-0455-7; https://doaj.org/toc/1471-2202 |
| DOI: | 10.1186/s12868-018-0455-7 |
| URL الوصول: | https://doaj.org/article/64222d0c51b445d4aa31b94e0a778f84 |
| رقم الأكسشن: | edsdoj.64222d0c51b445d4aa31b94e0a778f84 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 14712202 |
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| DOI: | 10.1186/s12868-018-0455-7 |