دورية أكاديمية
Trio preserves motor synapses and prolongs motor ability during aging
| العنوان: | Trio preserves motor synapses and prolongs motor ability during aging |
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| المؤلفون: | Soumya Banerjee, Samuel Vernon, Evelyne Ruchti, Greta Limoni, Wei Jiao, Jamshid Asadzadeh, Marine Van Campenhoudt, Brian D. McCabe |
| المصدر: | Cell Reports, Vol 43, Iss 6, Pp 114256- (2024) |
| بيانات النشر: | Elsevier, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Biology (General) |
| مصطلحات موضوعية: | CP: Neuroscience, CP: Cell biology, Biology (General), QH301-705.5 |
| الوصف: | Summary: The decline of motor ability is a hallmark feature of aging and is accompanied by degeneration of motor synaptic terminals. Consistent with this, Drosophila motor synapses undergo characteristic age-dependent structural fragmentation co-incident with diminishing motor ability. Here, we show that motor synapse levels of Trio, an evolutionarily conserved guanine nucleotide exchange factor (GEF), decline with age. We demonstrate that increasing Trio expression in adult Drosophila can abrogate age-dependent synaptic structural fragmentation, postpone the decline of motor ability, and maintain the capacity of motor synapses to sustain high-intensity neurotransmitter release. This preservative activity is conserved in transgenic human Trio, requires Trio Rac GEF function, and can also ameliorate synapse degeneration induced by depletion of miniature neurotransmission. Our results support a paradigm where the structural dissolution of motor synapses precedes and promotes motor behavioral diminishment and where intervening in this process can postpone the decline of motor function during aging. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2211-1247 64536920 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2211124724005849; https://doaj.org/toc/2211-1247 |
| DOI: | 10.1016/j.celrep.2024.114256 |
| URL الوصول: | https://doaj.org/article/645369202f144249961793464a9272d4 |
| رقم الأكسشن: | edsdoj.645369202f144249961793464a9272d4 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22111247 64536920 |
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| DOI: | 10.1016/j.celrep.2024.114256 |