دورية أكاديمية
Effect of Tarantula cubensis alcohol extract and Capecitabin combine in Colorectal Cancer rats
| العنوان: | Effect of Tarantula cubensis alcohol extract and Capecitabin combine in Colorectal Cancer rats |
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| المؤلفون: | Rahmi Canbar, Ozgur Ozdemir, Ahmet Levent Bas |
| المصدر: | Revista Científica, Vol 33, Iss 2 (2023) |
| بيانات النشر: | Universidad del Zulia, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Cattle LCC:Veterinary medicine |
| مصطلحات موضوعية: | Azoxymethane, Capecitabine, colorectal cancer, TCAE, Cattle, SF191-275, Veterinary medicine, SF600-1100 |
| الوصف: | Colon cancer (CRC) is one of the most common types of cancer in the world. In this study, the effects of Tarantula cubensis alcoholic extract (TCAE) and the Capecitabine in CRC were investigated. Wistar albino rats were divided into eight groups with 12 animals in each group: untreated healthy and CRC groups, healthy and CRC groups treated with TCAE or Capecitabine, and healthy and CRC groups treated with both TCAE and Capecitabine. Azoxymethane was used in all CRC groups. TCAE and Capecitabine were administered to the relevant groups starting in the 15th week. All rats were euthanized after 18 weeks, and tissue samples were collected. The mRNA levels of Bcl–2, Bax, and Cas–3 in the harvested tissues were determined using real–time PCR and histopathologically abnormal crypt foci (ACF) scores were determined. It was found that TCAE modulated the decreased Bax/Bcl–2 expression rate in the CC group, but had the opposite effect in healthy animals, which was significantly reduced compared to the healthy groups (P0.05). Importantly, single and combined use of TCAE and Capecitabine in rats with CRC significantly reduced ACF scores (P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Spanish; Castilian |
| تدمد: | 0798-2259 2521-9715 |
| Relation: | https://produccioncientificaluz.org/index.php/cientifica/article/view/40304; https://doaj.org/toc/0798-2259; https://doaj.org/toc/2521-9715 |
| DOI: | 10.52973/rcfcv-e33254 |
| URL الوصول: | https://doaj.org/article/64bc53d6fbd04690a720e5a098ac39d7 |
| رقم الأكسشن: | edsdoj.64bc53d6fbd04690a720e5a098ac39d7 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 07982259 25219715 |
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| DOI: | 10.52973/rcfcv-e33254 |