دورية أكاديمية
A Review of the Molecular Landscape of Adenoid Cystic Carcinoma of the Lacrimal Gland
| العنوان: | A Review of the Molecular Landscape of Adenoid Cystic Carcinoma of the Lacrimal Gland |
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| المؤلفون: | Sarah Kate Powell, Karina Kulakova, Susan Kennedy |
| المصدر: | International Journal of Molecular Sciences, Vol 24, Iss 18, p 13755 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | adenoid cystic carcinoma, lacrimal gland, MYB–NFIB translocation, Notch-signalling, DNA damage repair genes, epigenetics, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Adenoid cystic carcinoma (ACC) has a worldwide incidence of three to four cases per million population. Although more cases occur in the minor and major salivary glands, it is the most common lacrimal gland malignancy. ACC has a low-grade, indolent histological appearance, but is relentlessly progressive over time and has a strong proclivity to recur and/or metastasise. Current treatment options are limited to complete surgical excision and adjuvant radiotherapy. Intra-arterial systemic therapy is a recent innovation. Recurrent/metastatic disease is common due to perineural invasion, and it is largely untreatable as it is refractory to conventional chemotherapeutic agents. Given the rarity of this tumour, the molecular mechanisms that govern disease pathogenesis are poorly understood. There is an unmet, critical need to develop effective, personalised targeted therapies for the treatment of ACC in order to reduce morbidity and mortality associated with the disease. This review details the evidence relating to the molecular underpinnings of ACC of the lacrimal gland, including the MYB–NFIB chromosomal translocations, Notch-signalling pathway aberrations, DNA damage repair gene mutations and epigenetic modifications. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/24/18/13755; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms241813755 |
| URL الوصول: | https://doaj.org/article/64cf509885e7423590504de8f6007238 |
| رقم الأكسشن: | edsdoj.64cf509885e7423590504de8f6007238 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms241813755 |