دورية أكاديمية
Characterization of the Th cytokines profile in ovine spleen during early pregnancy
| العنوان: | Characterization of the Th cytokines profile in ovine spleen during early pregnancy |
|---|---|
| المؤلفون: | Ning Li, Zimo Zhao, Jiachen Bai, Baoliang Liu, Hao Mi, Leying Zhang, Guiping Li, Ling Yang |
| المصدر: | Journal of Applied Animal Research, Vol 47, Iss 1, Pp 386-393 (2019) |
| بيانات النشر: | Taylor & Francis Group, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Veterinary medicine |
| مصطلحات موضوعية: | pregnancy, spleen, t helper cytokines, sheep, Veterinary medicine, SF600-1100 |
| الوصف: | The spleen combines the innate and adaptive immune systems, and the early conceptus must regulate the maternal intrauterine immune and systemic immune response during early pregnancy in sheep. However, it is unclear whether early pregnancy exerts its effects on the characterization of the T helper (Th) cytokines profile in the spleen during early pregnancy in ewes. In this study, spleens were obtained at day 16 of the oestrous cycle and at days 13, 16 and 25 of pregnancy (n = 6 for each group) from ewes, and qRT-PCR, western blot and immunohistochemistry analysis were used to analyze the Th cytokines profile of the spleens. Our results showed that there was down-regulation of IFN-γ at days 13 and 16 of pregnancy, but there was upregulation of IL-2, IL-5 and IL-6 at day 25 of pregnancy, TNF-β at days 16 and 25 of pregnancy, and IL-4 and IL-10 in all pregnant groups. Immunohistochemistry results showed that the IL-6 protein was limited to the capsule, trabeculae and splenic cords. This paper reported, for the first time, that characterization of the Th cytokines profile varied in the maternal spleen during early pregnancy, which may be essential for successful pregnancy in sheep. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0971-2119 0974-1844 09712119 |
| Relation: | https://doaj.org/toc/0971-2119; https://doaj.org/toc/0974-1844 |
| DOI: | 10.1080/09712119.2019.1634077 |
| URL الوصول: | https://doaj.org/article/64f152008fcf44ee894d5b00e50a1c56 |
| رقم الأكسشن: | edsdoj.64f152008fcf44ee894d5b00e50a1c56 |
| قاعدة البيانات: | Directory of Open Access Journals |
PDF full text from Publisher 
Full Text Finder | تدمد: | 09712119 09741844 |
|---|---|
| DOI: | 10.1080/09712119.2019.1634077 |