دورية أكاديمية
Antimicrobial susceptibility, virulence determinant carriage and molecular characteristics of Staphylococcus aureus isolates associated with skin and soft tissue infections
العنوان: | Antimicrobial susceptibility, virulence determinant carriage and molecular characteristics of Staphylococcus aureus isolates associated with skin and soft tissue infections |
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المؤلفون: | Fangyou Yu, Yunling Liu, Jinnan Lv, Xiuqin Qi, Chaohui Lu, Yu Ding, Dan Li, Huanle Liu, Liangxing Wang |
المصدر: | Brazilian Journal of Infectious Diseases, Vol 19, Iss 6, Pp 614-622 (2015) |
بيانات النشر: | Elsevier, 2015. |
سنة النشر: | 2015 |
المجموعة: | LCC:Infectious and parasitic diseases LCC:Microbiology |
مصطلحات موضوعية: | Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502 |
الوصف: | A better understanding of the antimicrobial susceptibility, carriage of virulence determinants and molecular characteristics of Staphylococcus aureus isolates associated with skin and soft tissue infections (SSTIs) may provide further insights related to clinical outcomes with these infections. From January 2012 to September 2013, a total of 128 non-duplicate S. aureus isolates were recovered from patients with SSTIs. All 128 S. aureus SSTI isolates carried at least five virulence genes tested. Virulence genes detected among at least 70% of all tested isolates included hld (100%), hla (95.3%), icaA (96.9%), clf (99.2%), sdrC (79.7%), sdrD (70.3%), and sdrE (72.7%). The prevalence of MRSA isolates with 10 virulence genes tested (54.4%, 31/56) was significantly higher than that among MSSA isolates (35.2%, 25/71) (p 80.0%) of sdrC and sdrD, CC59 isolates had lower prevalence of these two virulence genes. All CC59 isolates were susceptible to gentamicin and trimethoprim/sulfamethoxazole, while CC5 and CC7 isolates had resistance rates to these two antimicrobials of 25.4% and 20.9%, and 40.0% and 40.0%, respectively. The resistance rates for tetracycline, clindamycin, and erythromycin among CC5 isolates were lower than among CC7 and CC59 isolates. In conclusion, the molecular typing of S. aureus SSTI isolates in the present study showed considerable heterogeneity. ST7 and ST630 became prevailing clones. Different S. aureus clones causing SSTIs were associated with specific antimicrobial resistance and virulence gene profiles. Keywords: Staphylococcus aureus, Skin and soft tissue infections, Molecular characteristic, Virulence genes |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1413-8670 |
Relation: | http://www.sciencedirect.com/science/article/pii/S1413867015001634; https://doaj.org/toc/1413-8670 |
DOI: | 10.1016/j.bjid.2015.08.006 |
URL الوصول: | https://doaj.org/article/64fbb69c662d4b2eae68954610337f3a |
رقم الأكسشن: | edsdoj.64fbb69c662d4b2eae68954610337f3a |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 14138670 |
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DOI: | 10.1016/j.bjid.2015.08.006 |