دورية أكاديمية
أعرض في EDS

3213 Unraveling the role of Phospholamban (PLN) in humans via the characterization of Induced Pluripotent Stem Cell (iPSC) Cardiomyocytes (CM) derived from carriers of a lethal PLN mutation

التفاصيل البيبلوغرافية
العنوان: 3213 Unraveling the role of Phospholamban (PLN) in humans via the characterization of Induced Pluripotent Stem Cell (iPSC) Cardiomyocytes (CM) derived from carriers of a lethal PLN mutation
المؤلفون: Maria Giovanna Trivieri, Francesca Stillitano, Delaine Ceholski, Irene Turnbull, Kevin Costa, Thomas Weber, Kenneth Fish, Evangelia Kranias, Roger Hajjar
المصدر: Journal of Clinical and Translational Science, Vol 3, Pp 26-26 (2019)
بيانات النشر: Cambridge University Press, 2019.
سنة النشر: 2019
المجموعة: LCC:Medicine
مصطلحات موضوعية: Medicine
الوصف: OBJECTIVES/SPECIFIC AIMS: To study the biology of Phosholamban (PLN) in a human relevant model. METHODS/STUDY POPULATION: State of the art stem-cell technologies using iPSC-CMs derived from carriers of a lethal PLN mutation. RESULTS/ANTICIPATED RESULTS: Our preliminary data demonstrate that this particular PLN mutation (L39) results in reduced expression and mis-localization of PLN as well as increased incidence of early after depolarization in isolated iPSC-CMs. DISCUSSION/SIGNIFICANCE OF IMPACT: Phospholamban (PLN) is a critical regulator of Ca++ homeostasis yet many uncertainties still remain regarding its role in humans. Our study will provide unique insights into the pathophysiology of this protein in HF.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2059-8661
Relation: https://www.cambridge.org/core/product/identifier/S2059866119000621/type/journal_article; https://doaj.org/toc/2059-8661
DOI: 10.1017/cts.2019.62
URL الوصول: https://doaj.org/article/add6508bc87d453fa71a94fb3a120355
رقم الأكسشن: edsdoj.6508bc87d453fa71a94fb3a120355
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20598661
DOI:10.1017/cts.2019.62