Endogenous formaldehyde scavenges cellular glutathione resulting in redox disruption and cytotoxicity

التفاصيل البيبلوغرافية
العنوان:	Endogenous formaldehyde scavenges cellular glutathione resulting in redox disruption and cytotoxicity
المؤلفون:	Carla Umansky, Agustín E. Morellato, Matthias Rieckher, Marco A. Scheidegger, Manuela R. Martinefski, Gabriela A. Fernández, Oleg Pak, Ksenia Kolesnikova, Hernán Reingruber, Mariela Bollini, Gerry P. Crossan, Natascha Sommer, María Eugenia Monge, Björn Schumacher, Lucas B. Pontel
المصدر:	Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
بيانات النشر:	Nature Portfolio, 2022.
سنة النشر:	2022
المجموعة:	LCC:Science
مصطلحات موضوعية:	Science
الوصف:	Formaldehyde (FA) is known to exert cytotoxicity through DNA damage. Here, the authors show that FA also triggers cellular redox imbalance by reacting with glutathione (GSH), and that FA cytotoxicity is prevented by GSH synthesis and by ADH5, an enzyme that metabolizes FA-GSH products.
نوع الوثيقة:	article
وصف الملف:	electronic resource
اللغة:	English
تدمد:	2041-1723
Relation:	https://doaj.org/toc/2041-1723
DOI:	10.1038/s41467-022-28242-7
URL الوصول:	https://doaj.org/article/653aae910d4d4b0192f151bf36477da9
رقم الأكسشن:	edsdoj.653aae910d4d4b0192f151bf36477da9
قاعدة البيانات:	Directory of Open Access Journals

الوصف
تدمد:	20411723
DOI:	10.1038/s41467-022-28242-7