دورية أكاديمية
Photo-/thermo-responsive bioink for improved printability in extrusion-based bioprinting
| العنوان: | Photo-/thermo-responsive bioink for improved printability in extrusion-based bioprinting |
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| المؤلفون: | Seo Hyung Moon, Tae Yoon Park, Hyung Joon Cha, Yun Jung Yang |
| المصدر: | Materials Today Bio, Vol 25, Iss , Pp 100973- (2024) |
| بيانات النشر: | Elsevier, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine (General) LCC:Biology (General) |
| مصطلحات موضوعية: | Silk fibroin, Iota-carrageenan, Bioink, Extrusion-based bioprinting, Dual-crosslinking, Medicine (General), R5-920, Biology (General), QH301-705.5 |
| الوصف: | Extrusion-based bioprinting has demonstrated significant potential for manufacturing constructs, particularly for 3D cell culture. However, there is a greatly limited number of bioink candidates exploited with extrusion-based bioprinting, as they meet the opposing requirements for printability with indispensable rheological features and for biochemical functionality with desirable microenvironment. In this study, a blend of silk fibroin (SF) and iota-carrageenan (CG) was chosen as a cell-friendly printable material. The SF/CG ink exhibited suitable viscosity and shear-thinning properties, coupled with the rapid sol-gel transition of CG. By employing photo-crosslinking of SF, the printability with Pr value close to 1 and structural integrity of the 3D constructs were significantly improved within a matter of seconds. The printed constructs demonstrated a Young's modulus of approximately 250 kPa, making them suitable for keratinocyte and myoblast cell culture. Furthermore, the high cell adhesiveness and viability (maximum >98%) of the loaded cells underscored the considerable potential of this 3D culture scaffold applied for skin and muscle tissues, which can be easily manipulated using an extrusion-based bioprinter. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2590-0064 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2590006424000322; https://doaj.org/toc/2590-0064 |
| DOI: | 10.1016/j.mtbio.2024.100973 |
| URL الوصول: | https://doaj.org/article/65785c4c7e5843a5b7e2b81f851d2a4a |
| رقم الأكسشن: | edsdoj.65785c4c7e5843a5b7e2b81f851d2a4a |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 25900064 |
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| DOI: | 10.1016/j.mtbio.2024.100973 |