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Autophagic Regulation of p62 is Critical for Cancer Therapy

التفاصيل البيبلوغرافية
العنوان: Autophagic Regulation of p62 is Critical for Cancer Therapy
المؤلفون: Md. Ariful Islam, Mopa Alina Sooro, Pinghu Zhang
المصدر: International Journal of Molecular Sciences, Vol 19, Iss 5, p 1405 (2018)
بيانات النشر: MDPI AG, 2018.
سنة النشر: 2018
المجموعة: LCC:Biology (General)
LCC:Chemistry
مصطلحات موضوعية: p62, PB1, self-oligomerization, autophagy, apoptosis, cancer, therapy, Biology (General), QH301-705.5, Chemistry, QD1-999
الوصف: Sequestosome1 (p62/SQSTM 1) is a multidomain protein that interacts with the autophagy machinery as a key adaptor of target cargo. It interacts with phagophores through the LC3-interacting (LIR) domain and with the ubiquitinated protein aggregates through the ubiquitin-associated domain (UBA) domain. It sequesters the target cargo into inclusion bodies by its PB1 domain. This protein is further the central hub that interacts with several key signaling proteins. Emerging evidence implicates p62 in the induction of multiple cellular oncogenic transformations. Indeed, p62 upregulation and/or reduced degradation have been implicated in tumor formation, cancer promotion as well as in resistance to therapy. It has been established that the process of autophagy regulates the levels of p62. Autophagy-dependent apoptotic activity of p62 is recently being reported. It is evident that p62 plays a critical role in both autophagy and apoptosis. Therefore in this review we discuss the role of p62 in autophagy, apoptosis and cancer through its different domains and outline the importance of modulating cellular levels of p62 in cancer therapeutics.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1422-0067
Relation: http://www.mdpi.com/1422-0067/19/5/1405; https://doaj.org/toc/1422-0067
DOI: 10.3390/ijms19051405
URL الوصول: https://doaj.org/article/d6585b84df71485f939f599a0101957a
رقم الأكسشن: edsdoj.6585b84df71485f939f599a0101957a
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14220067
DOI:10.3390/ijms19051405