دورية أكاديمية
TEM8 functions as a receptor for uPA and mediates uPA-stimulated EGFR phosphorylation
| العنوان: | TEM8 functions as a receptor for uPA and mediates uPA-stimulated EGFR phosphorylation |
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| المؤلفون: | Lian-Cheng Zhang, Yong Shao, Li-Hua Gao, Jin Liu, Yong-Yi Xi, Yin Xu, Chutse Wu, Wei Chen, Hui-Peng Chen, You-Liang Wang, Hai-Feng Duan, Xian-Wen Hu |
| المصدر: | Cell Communication and Signaling, Vol 16, Iss 1, Pp 1-16 (2018) |
| بيانات النشر: | BMC, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Medicine LCC:Cytology |
| مصطلحات موضوعية: | EGFR, Phosphorylation, Receptor, TEM8, uPA, Medicine, Cytology, QH573-671 |
| الوصف: | Abstract Background TEM8 is a cell membrane protein predominantly expressed in tumor endothelium, which serves as a receptor for the protective antigen (PA) of anthrax toxin. However, the physiological ligands for TEM8 remain unknown. Results Here we identified uPA as an interacting partner of TEM8. Binding of uPA stimulated the phosphorylation of TEM8 and augmented phosphorylation of EGFR and ERK1/2. Finally, TEM8-Fc, a recombinant fusion protein comprising the extracellular domain of human TEM8 linked to the Fc portion of human IgG1, efficiently abrogated the interaction between uPA and TEM8, blocked uPA-induced migration of HepG2 cells in vitro and inhibited the growth and metastasis of human MCF-7 xenografts in vivo. uPA, TEM8 and EGFR overexpression and ERK1/2 phosphorylation were found co-located on frozen cancer tissue sections. Conclusions Taken together, our data provide evidence that TEM8 is a novel receptor for uPA, which may play a significant role in the regulation of tumor growth and metastasis. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1478-811X |
| Relation: | http://link.springer.com/article/10.1186/s12964-018-0272-8; https://doaj.org/toc/1478-811X |
| DOI: | 10.1186/s12964-018-0272-8 |
| URL الوصول: | https://doaj.org/article/660858a22ea9434fb7ecb5b225266c2d |
| رقم الأكسشن: | edsdoj.660858a22ea9434fb7ecb5b225266c2d |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1478811X |
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| DOI: | 10.1186/s12964-018-0272-8 |