دورية أكاديمية
Protective effects of melatonin receptor agonists on endotoxin-ınduced uveitis in rats
| العنوان: | Protective effects of melatonin receptor agonists on endotoxin-ınduced uveitis in rats |
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| المؤلفون: | Tugba Nurcan Yuksel, Muhammed Yayla, Duygu Kose, Zekai Halici, Erdinc Bozkurt, Erdem Toktay |
| المصدر: | Iranian Journal of Basic Medical Sciences, Vol 26, Iss 5, Pp 540-548 (2023) |
| بيانات النشر: | Mashhad University of Medical Sciences, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | lipopolysaccharides, melatonin, oxidative stress, rats, uveitis, Medicine |
| الوصف: | Objective(s): Melatonin has an important role in regulating a variety of physiological functions of the body. We investigated the protective effects of Agomelatine (AGO) and Ramelteon (RAME) on Endotoxin-Induced Uveitis (EIU) in rats.Materials and Methods: 70 rats were randomly divided into fourteen groups. Healthy group )normal saline, IP(, Uveitis group (200 μg/kg lipopolysaccharide (LPS), SC), DEX group (200 μg/kg LPS plus 1 mg/kg dexamethasone, IP), AGO20 group received 200 μg/kg LPS plus 20 mg/kg AGO, AGO40 group received 200 μg/kg LPS plus 40 mg/kg AGO, RAME2 group received 200 μg/kg LPS plus 2 mg/kg RAME, and group RAME4 received 200 μg/kg LPS plus 4 mg/kg RAME. Each group had two subgroups: the 3rd and 24th hour. The eye tissues were collected and investigated biomicroscopically (clinical manifestations and scoring, molecularly(qRT-PCR analyses of Tumor Necrosis Factor-α (TNF-α), vascular endothelial growth factor(VEGF), and Caspase 3 and Caspase 9 mRNA expression), biochemically (Superoxide dismutase activity, Glutathione, and Malondialdehyde levels) and histopathologically (staining with Harris Hematoxylin and Eosin Y).Results: Melatonin receptor agonist treatment reduced the clinical score count of ocular inflammation in the uveitic rats. TNF-α, VEGF, Caspase 9, and Caspase 3 levels markedly decreased in the uveitic rats. Melatonin receptor agonists significantly ameliorated fixed changes in GSH, SOD, and MDA levels. Melatonin receptor agonists also ameliorated histopathological injury in eye tissues associated with uveitis.Conclusion: Melatonin receptor agonists ameliorated the inflammatory response in EIU. These findings suggest that melatonin receptor agonists may represent a potential novel therapeutic drug for uveitis treatment. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2008-3866 2008-3874 |
| Relation: | https://ijbms.mums.ac.ir/article_21871_e9f8191fe63e358d43258709eb8b59a5.pdf; https://doaj.org/toc/2008-3866; https://doaj.org/toc/2008-3874 |
| DOI: | 10.22038/ijbms.2023.67297.14749 |
| URL الوصول: | https://doaj.org/article/660b06ceb7694380a639d388518474f2 |
| رقم الأكسشن: | edsdoj.660b06ceb7694380a639d388518474f2 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20083866 20083874 |
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| DOI: | 10.22038/ijbms.2023.67297.14749 |