دورية أكاديمية
Comparative genomics of Cluster O mycobacteriophages.
| العنوان: | Comparative genomics of Cluster O mycobacteriophages. |
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| المؤلفون: | Steven G Cresawn, Welkin H Pope, Deborah Jacobs-Sera, Charles A Bowman, Daniel A Russell, Rebekah M Dedrick, Tamarah Adair, Kirk R Anders, Sarah Ball, David Bollivar, Caroline Breitenberger, Sandra H Burnett, Kristen Butela, Deanna Byrnes, Sarah Carzo, Kathleen A Cornely, Trevor Cross, Richard L Daniels, David Dunbar, Ann M Findley, Chris R Gissendanner, Urszula P Golebiewska, Grant A Hartzog, J Robert Hatherill, Lee E Hughes, Chernoh S Jalloh, Carla De Los Santos, Kevin Ekanem, Sphindile L Khambule, Rodney A King, Christina King-Smith, Karen Klyczek, Greg P Krukonis, Christian Laing, Jonathan S Lapin, A Javier Lopez, Sipho M Mkhwanazi, Sally D Molloy, Deborah Moran, Vanisha Munsamy, Eddie Pacey, Ruth Plymale, Marianne Poxleitner, Nathan Reyna, Joel F Schildbach, Joseph Stukey, Sarah E Taylor, Vassie C Ware, Amanda L Wellmann, Daniel Westholm, Donna Wodarski, Michelle Zajko, Thabiso S Zikalala, Roger W Hendrix, Graham F Hatfull |
| المصدر: | PLoS ONE, Vol 10, Iss 3, p e0118725 (2015) |
| بيانات النشر: | Public Library of Science (PLoS), 2015. |
| سنة النشر: | 2015 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | Mycobacteriophages--viruses of mycobacterial hosts--are genetically diverse but morphologically are all classified in the Caudovirales with double-stranded DNA and tails. We describe here a group of five closely related mycobacteriophages--Corndog, Catdawg, Dylan, Firecracker, and YungJamal--designated as Cluster O with long flexible tails but with unusual prolate capsids. Proteomic analysis of phage Corndog particles, Catdawg particles, and Corndog-infected cells confirms expression of half of the predicted gene products and indicates a non-canonical mechanism for translation of the Corndog tape measure protein. Bioinformatic analysis identifies 8-9 strongly predicted SigA promoters and all five Cluster O genomes contain more than 30 copies of a 17 bp repeat sequence with dyad symmetry located throughout the genomes. Comparison of the Cluster O phages provides insights into phage genome evolution including the processes of gene flux by horizontal genetic exchange. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1932-6203 |
| Relation: | http://europepmc.org/articles/PMC4351075?pdf=render; https://doaj.org/toc/1932-6203 |
| DOI: | 10.1371/journal.pone.0118725 |
| URL الوصول: | https://doaj.org/article/66186ddc8b2f4725ae9be65165e930d3 |
| رقم الأكسشن: | edsdoj.66186ddc8b2f4725ae9be65165e930d3 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0118725 |