دورية أكاديمية
Beneficial Effects of Probiotic Lactobacillus paraplantarum BGCG11 on Pancreatic and Duodenum Function in Diabetic Rats
| العنوان: | Beneficial Effects of Probiotic Lactobacillus paraplantarum BGCG11 on Pancreatic and Duodenum Function in Diabetic Rats |
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| المؤلفون: | Mirjana Mihailović, Svetlana Soković Bajić, Jelena Arambašić Jovanović, Emilija Brdarić, Svetlana Dinić, Nevena Grdović, Aleksandra Uskoković, Jovana Rajić, Marija Đorđević, Maja Tolinački, Nataša Golić, Milica Živković, Melita Vidaković |
| المصدر: | International Journal of Molecular Sciences, Vol 25, Iss 14, p 7697 (2024) |
| بيانات النشر: | MDPI AG, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | diabetes, glycohemoglobin, probiotic therapy, gut health, pancreas histology, zonulin, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Diabetes mellitus, as a chronic metabolic disorder, significantly impacts the pancreas and among other organs, affects duodenal function. Emerging evidence suggests that probiotics can exert beneficial effects on gut health and metabolism. In our previous research, we evaluated the probiotic Lactobacillus paraplantarum BGCG11 primarily for its protective properties against diabetic rats’ damaged liver and kidneys. In this work, we further examined the effects of probiotic strain BGCG11 on the function of the duodenum and pancreas in diabetic rats. We explored the potential mechanisms underlying the probiotic’s effects, focusing on general indicators of diabetes, the architecture and morphology of pancreatic islets, duodenal integrity (measuring the transfer of fluid and serum zonulin level), and the modulation of gut microbiota composition. Our findings reveal the protective and regulatory roles of L. paraplantarum BGCG11 in mitigating diabetes-induced pancreatic and duodenal dysfunction regardless of its application time (pre- or post-treatment), highlighting its therapeutic potential in managing diabetes-related gastrointestinal complications. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/25/14/7697; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms25147697 |
| URL الوصول: | https://doaj.org/article/661e52a6506a439c8f982d6f4880680e |
| رقم الأكسشن: | edsdoj.661e52a6506a439c8f982d6f4880680e |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms25147697 |