دورية أكاديمية
Anti-Obesity Effect and Signaling Mechanism of Potassium Poly-γ-Glutamate Produced by Bacillus subtilis Chungkookjang in High-Fat Diet-Induced Obese Mice
| العنوان: | Anti-Obesity Effect and Signaling Mechanism of Potassium Poly-γ-Glutamate Produced by Bacillus subtilis Chungkookjang in High-Fat Diet-Induced Obese Mice |
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| المؤلفون: | Seung-Hyeon Lee, Jiwon Choi, Jae Young Park, Ha-Rim Kim, Myeongkuk Shim, Kyunghyun Im, Hyeonjeong Choe, Jae-Chul Choi, Young-Chul Park, Tae-Gyu Lim, Hyangyim Seo, Hansu Jang, Boung-Jun Oh, Seon-Young Kim, Mi Hee Park |
| المصدر: | Nutrients, Vol 16, Iss 6, p 809 (2024) |
| بيانات النشر: | MDPI AG, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Nutrition. Foods and food supply |
| مصطلحات موضوعية: | potassium poly-γ-glutamate, Chungkookjang, obesity, inflammation, insulin resistance, Nutrition. Foods and food supply, TX341-641 |
| الوصف: | The purpose of this work was to examine the effects of potassium poly-γ-glutamate (PGA-K) on mice fed a high-fat diet consisting of 60% of total calories for 12 weeks. PGA-K administration reduced the increase in body weight, epididymal fat, and liver weight caused by a high-fat diet compared to the obese group. The triglyceride, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol levels, which are blood lipid indicators, were significantly increased in the obese group but were significantly decreased in the PGA-K-treated group. The administration of PGA-K resulted in a significant inhibition of pro-inflammatory cytokines, including tumor necrosis factor α and interleukin 6. Moreover, the levels of leptin and insulin, which are insulin resistance indicators, significantly increased in the obese group but were significantly decreased in the PGA-K-treated group. These results suggest that PGA-K exhibits a protective effect against obesity induced by a high-fat diet, underscoring its potential as a candidate for obesity treatment. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2072-6643 00007951 |
| Relation: | https://www.mdpi.com/2072-6643/16/6/809; https://doaj.org/toc/2072-6643 |
| DOI: | 10.3390/nu16060809 |
| URL الوصول: | https://doaj.org/article/663f0000795148bbbc70abc116344082 |
| رقم الأكسشن: | edsdoj.663f0000795148bbbc70abc116344082 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20726643 00007951 |
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| DOI: | 10.3390/nu16060809 |