دورية أكاديمية
Small molecule targeting FOXM1 DNA binding domain exhibits anti-tumor activity in ovarian cancer
العنوان: | Small molecule targeting FOXM1 DNA binding domain exhibits anti-tumor activity in ovarian cancer |
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المؤلفون: | Zaixin Zhang, Si-tu Xue, Yan Gao, Yingwei Li, Ziying Zhou, Jing Wang, Zhuorong Li, Zhaojian Liu |
المصدر: | Cell Death Discovery, Vol 8, Iss 1, Pp 1-8 (2022) |
بيانات النشر: | Nature Publishing Group, 2022. |
سنة النشر: | 2022 |
المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens LCC:Cytology |
مصطلحات موضوعية: | Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671 |
الوصف: | Abstract FOXM1 is a potent oncogenic transcription factor essential for cancer initiation, progression, and drug resistance. FOXM1 regulatory network is a major predictor of adverse outcomes in various human cancers. Inhibition of FOXM1 transcription factor function is a potential strategy in cancer treatment. In this study, we performed structure-based in silico screening to discover small molecules targeting the FOXM1 DNA-binding domain (DBD). Compound XST-20 was identified to effectively suppress FOXM1 transcriptional activities and inhibit ovarian cancer cell proliferation. XST-20 directly interacts with the FOXM1 DNA-binding domain determined by SPR assay. Furthermore, XST-20 was found to significantly reduce the colony-forming efficiency and induce cell cycle arrest and apoptosis. Our study provides a lead compound of FOXM1 inhibitor which may serve as a potential targeted therapy agent for ovarian cancer. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 2058-7716 |
Relation: | https://doaj.org/toc/2058-7716 |
DOI: | 10.1038/s41420-022-01070-w |
URL الوصول: | https://doaj.org/article/669365b9dc2847d791e36c8d8d4095d8 |
رقم الأكسشن: | edsdoj.669365b9dc2847d791e36c8d8d4095d8 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 20587716 |
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DOI: | 10.1038/s41420-022-01070-w |