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Small molecule targeting FOXM1 DNA binding domain exhibits anti-tumor activity in ovarian cancer

التفاصيل البيبلوغرافية
العنوان: Small molecule targeting FOXM1 DNA binding domain exhibits anti-tumor activity in ovarian cancer
المؤلفون: Zaixin Zhang, Si-tu Xue, Yan Gao, Yingwei Li, Ziying Zhou, Jing Wang, Zhuorong Li, Zhaojian Liu
المصدر: Cell Death Discovery, Vol 8, Iss 1, Pp 1-8 (2022)
بيانات النشر: Nature Publishing Group, 2022.
سنة النشر: 2022
المجموعة: LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
LCC:Cytology
مصطلحات موضوعية: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671
الوصف: Abstract FOXM1 is a potent oncogenic transcription factor essential for cancer initiation, progression, and drug resistance. FOXM1 regulatory network is a major predictor of adverse outcomes in various human cancers. Inhibition of FOXM1 transcription factor function is a potential strategy in cancer treatment. In this study, we performed structure-based in silico screening to discover small molecules targeting the FOXM1 DNA-binding domain (DBD). Compound XST-20 was identified to effectively suppress FOXM1 transcriptional activities and inhibit ovarian cancer cell proliferation. XST-20 directly interacts with the FOXM1 DNA-binding domain determined by SPR assay. Furthermore, XST-20 was found to significantly reduce the colony-forming efficiency and induce cell cycle arrest and apoptosis. Our study provides a lead compound of FOXM1 inhibitor which may serve as a potential targeted therapy agent for ovarian cancer.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2058-7716
Relation: https://doaj.org/toc/2058-7716
DOI: 10.1038/s41420-022-01070-w
URL الوصول: https://doaj.org/article/669365b9dc2847d791e36c8d8d4095d8
رقم الأكسشن: edsdoj.669365b9dc2847d791e36c8d8d4095d8
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20587716
DOI:10.1038/s41420-022-01070-w