دورية أكاديمية
Age-specific effectiveness of a tuberculosis screening intervention in children.
| العنوان: | Age-specific effectiveness of a tuberculosis screening intervention in children. |
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| المؤلفون: | Meredith B Brooks, Melanie M Dubois, Amyn A Malik, Junaid F Ahmed, Sara Siddiqui, Salman Khan, Manzoor Brohi, Teerath Das Valecha, Farhana Amanullah, Mercedes C Becerra, Hamidah Hussain |
| المصدر: | PLoS ONE, Vol 17, Iss 2, p e0264216 (2022) |
| بيانات النشر: | Public Library of Science (PLoS), 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | ObjectiveTo apply a cascade-of-care framework to evaluate the effectiveness-by age of the child-of an intensified tuberculosis patient-finding intervention.DesignFrom a prospective screening program at four hospitals in Pakistan (2014-2016) we constructed a care cascade comprising six steps: screened, positive screen, evaluated, diagnosed, started treatment, and successful outcome. We evaluated the cascade by each year of age from 0 to 14 and report the age-specific mean proportion and standard deviation.ResultsOn average across all ages, only 12.5% (standard deviation: 2.0%) of children with a positive screen were not evaluated. Among children who had a complete evaluation, the highest percentages of children diagnosed with tuberculosis were observed in children 0-4 (mean: 31.9%; standard deviation: 4.8%), followed by lower percentages in children 5-9 (mean: 22.4%; standard deviation: 2.2%), and 10-14 (mean: 26.0%; standard deviation:5.4%). Nearly all children diagnosed with tuberculosis initiated treatment, and an average of 93.3% (standard deviation: 3.3%) across all ages had successful treatment outcomes.ConclusionsThis intervention was highly effective across ages 0-14 years. Our study illustrates the utility of applying operational analyses of age-stratified cascades to identify age-specific gaps in pediatric tuberculosis care that can guide future, novel interventions to close these gaps. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1932-6203 |
| Relation: | https://doaj.org/toc/1932-6203 |
| DOI: | 10.1371/journal.pone.0264216 |
| URL الوصول: | https://doaj.org/article/66a2756653784ec7a92d9f4d1738b86c |
| رقم الأكسشن: | edsdoj.66a2756653784ec7a92d9f4d1738b86c |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0264216 |