دورية أكاديمية
Corresponding Changes of Autophagy‐Related Genes and Proteins in Different Stages of Knee Osteoarthritis: An Animal Model Study
| العنوان: | Corresponding Changes of Autophagy‐Related Genes and Proteins in Different Stages of Knee Osteoarthritis: An Animal Model Study |
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| المؤلفون: | Shao‐long Zhang, Ke‐shi Zhang, Jun‐feng Wang, Yi‐chuan Wang, Hui Zhang, Chong Tang, Zheng Pei, Zhen‐peng Guan |
| المصدر: | Orthopaedic Surgery, Vol 14, Iss 3, Pp 595-604 (2022) |
| بيانات النشر: | Wiley, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Orthopedic surgery |
| مصطلحات موضوعية: | Animal models, Autophagy, Autophagy‐related proteins, Chondrocytes, Osteoarthritis, Orthopedic surgery, RD701-811 |
| الوصف: | Objective To investigate the effect of autophagy expression levels of different weight‐bearing states and different stages of osteoarthritis in animal models, as well as the corresponding mechanisms. Methods We used the male Sprague–Dawley (SD) rats (12‐week‐old, SPF) to establish the OA animal models by modified Hulth method, and grouped animal models according to the length of time after surgery and different weight‐bearing areas. RT‐qPCR was carried out for detection of autophagy‐related genes such as Atg7, Atg12, P62, etc. Western blot analysis was used to detect the expression levels of corresponding autophagy‐related proteins such as LC3B, P62, etc. T test was performed for statistical analysis to compare different groups, while the differences were deemed statistically significant with P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1757-7861 1757-7853 |
| Relation: | https://doaj.org/toc/1757-7853; https://doaj.org/toc/1757-7861 |
| DOI: | 10.1111/os.13057 |
| URL الوصول: | https://doaj.org/article/66ba07daa153418b91f7a0f058df084d |
| رقم الأكسشن: | edsdoj.66ba07daa153418b91f7a0f058df084d |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17577861 17577853 |
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| DOI: | 10.1111/os.13057 |