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Streptococcus pneumoniae utilizes a novel dynamin independent pathway for entry and persistence in brain endothelium

التفاصيل البيبلوغرافية
العنوان: Streptococcus pneumoniae utilizes a novel dynamin independent pathway for entry and persistence in brain endothelium
المؤلفون: Manalee V. Surve, Shruti Apte, Smita Bhutda, Kshama G. Kamath, Kwang S. Kim, Anirban Banerjee
المصدر: Current Research in Microbial Sciences, Vol 1, Iss , Pp 62-68 (2020)
بيانات النشر: Elsevier, 2020.
سنة النشر: 2020
المجموعة: LCC:Microbiology
LCC:Genetics
مصطلحات موضوعية: Streptococcus pneumoniae, Blood-brain barrier, Clathrin mediated endocytosis, Caveolae, Dynamin independent endocytosis, Microbiology, QR1-502, Genetics, QH426-470
الوصف: Adoption of an endocytosis route promoting safe intracellular trafficking is a pre-requisite for development of invasive diseases by Streptococcus pneumoniae (SPN). We aim to explore the contribution of various endocytic routes in internalization and survival of SPN in blood brain barrier (BBB), a key event in development of pneumococcal meningitis. Pneumococcal entry and survival in brain endothelial cells were evaluated following treatment with combinations of inhibitors to block multiple endocytosis pathways leaving a single entry port open. Entry of SPN into brain endothelium through a novel dynamin independent pathway dictates a separate downstream trafficking itinerary. This allows SPN to evade lysosomal degradation, potentially promoting safe transit across BBB, leading to development of meningitis.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2666-5174
Relation: http://www.sciencedirect.com/science/article/pii/S2666517420300080; https://doaj.org/toc/2666-5174
DOI: 10.1016/j.crmicr.2020.08.001
URL الوصول: https://doaj.org/article/da66d0a74e524257ad0b491216b19235
رقم الأكسشن: edsdoj.66d0a74e524257ad0b491216b19235
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:26665174
DOI:10.1016/j.crmicr.2020.08.001