دورية أكاديمية
T Cell Reactivity against Mycolyl Transferase Antigen 85 of M. tuberculosis in HIV-TB Coinfected Subjects and in AIDS Patients Suffering from Tuberculosis and Nontuberculous Mycobacterial Infections
| العنوان: | T Cell Reactivity against Mycolyl Transferase Antigen 85 of M. tuberculosis in HIV-TB Coinfected Subjects and in AIDS Patients Suffering from Tuberculosis and Nontuberculous Mycobacterial Infections |
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| المؤلفون: | Pascal Launois, Annie Drowart, Eliane Bourreau, Pierre Couppie, Claire-Michèle Farber, Jean-Paul Van Vooren, Kris Huygen |
| المصدر: | Clinical and Developmental Immunology, Vol 2011 (2011) |
| بيانات النشر: | Wiley, 2011. |
| سنة النشر: | 2011 |
| المجموعة: | LCC:Immunologic diseases. Allergy |
| مصطلحات موضوعية: | Immunologic diseases. Allergy, RC581-607 |
| الوصف: | The mycolyl transferase antigen 85 complex is a major secreted protein family from mycobacterial culture filtrate, demonstrating powerful T cell stimulatory properties in most HIV-negative, tuberculin-positive volunteers with latent M.tuberculosis infection and only weak responses in HIV-negative tuberculosis patients. Here, we have analyzed T cell reactivity against PPD and Ag85 in HIV-infected individuals, without or with clinical symptoms of tuberculosis, and in AIDS patients with disease caused by nontuberculous mycobacteria. Whereas responses to PPD were not significantly different in HIV-negative and HIV-positive tuberculin-positive volunteers, responses to Ag85 were significantly decreased in the HIV-positive (CDC-A and CDC-B) group. Tuberculosis patients demonstrated low T cell reactivity against Ag85, irrespective of HIV infection, and finally AIDS patients suffering from NTM infections were completely nonreactive to Ag85. A one-year follow-up of twelve HIV-positive tuberculin-positive individuals indicated a decreased reactivity against Ag85 in patients developing clinical tuberculosis, highlighting the protective potential of this antigen. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1740-2522 1740-2530 |
| Relation: | https://doaj.org/toc/1740-2522; https://doaj.org/toc/1740-2530 |
| DOI: | 10.1155/2011/640309 |
| URL الوصول: | https://doaj.org/article/66db2121e91c4d2b9649a0521cd714d8 |
| رقم الأكسشن: | edsdoj.66db2121e91c4d2b9649a0521cd714d8 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17402522 17402530 |
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| DOI: | 10.1155/2011/640309 |