دورية أكاديمية
Thymus and activation-regulated chemokine (TARC)/CCL17 and IgE are associated with elderly asthmatics
| العنوان: | Thymus and activation-regulated chemokine (TARC)/CCL17 and IgE are associated with elderly asthmatics |
|---|---|
| المؤلفون: | Kyung Mi Jo, Hyo Kyung Lim, Jae Woong Sull, Eugene Choi, Ji-Sook Lee, Mee Ae Cheong, Min Hwa Hong, Yoori Kim, In Sik Kim |
| المصدر: | Immunity & Ageing, Vol 15, Iss 1, Pp 1-7 (2018) |
| بيانات النشر: | BMC, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Immunologic diseases. Allergy LCC:Geriatrics |
| مصطلحات موضوعية: | Asthma, Aging, TARC, Allergen-specific IgE, Immunologic diseases. Allergy, RC581-607, Geriatrics, RC952-954.6 |
| الوصف: | Abstract Background The pathogenesis of asthma, which is an allergic lung disease, is associated with a variety of allergens such as house dust mite, pollen, and mould, IgE containing serum IgE and allergen-specific-IgE, and inflammatory cytokines including thymus and activation-regulated chemokine (TARC)/CCL17. Because aging is an essential factor in the pathogenesis of asthma, we examined biomarkers related to asthmatic subjects depending on age. Results Physiological indices such as FEV1(forced expiratory capacity in 1 s), FEV1 (% predicted), and FEV1/FVC(forced vital capacity) (%) in asthmatic subjects were lower than those in normal subjects. Total IgE, Der p1 specific IgE, and Der f1 specific IgE were elevated in serum of asthmatics relative to normal individuals. Regulated on activation, normal T cell expressed and secreted (RANTES)/CCL5 in serum and interleukin 6 (IL-6), interleukin 8 (IL-8), monocyte chemoattractant protein (MCP)-1/CCL2, RANTES, and macrophage inflammatory protein (MIP)-1α/CCL3 in bronchoalveolar lavage fluid (BALF) of asthmatic subjects were higher than in normal individuals. Upon classification of experimental groups depending on age, physiological indices and Der p1-specific IgE (class) were decreased in middle aged adult and elderly adult groups relative to the young adult group. TARC levels in serum were strongly elevated in the elderly adult group relative to the young adult and the middle aged adult groups. TARC in serum was related to total IgE in serum in the elderly adult group. Conclusions Taken together, although TARC in serum and BALF is not different between normal and asthmatic individuals, TARC increases in serum of elderly asthmatic subjects. The level of TARC has a positive effect on the level of IgE in the elderly adult group. These findings may help us better understand the relationship of pathogenesis of allergic diseases and aging. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1742-4933 |
| Relation: | http://link.springer.com/article/10.1186/s12979-018-0118-7; https://doaj.org/toc/1742-4933 |
| DOI: | 10.1186/s12979-018-0118-7 |
| URL الوصول: | https://doaj.org/article/6707e9ee55e84408bd6291f891b9a36b |
| رقم الأكسشن: | edsdoj.6707e9ee55e84408bd6291f891b9a36b |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 17424933 |
|---|---|
| DOI: | 10.1186/s12979-018-0118-7 |