دورية أكاديمية
Accelerated sarcopenia precedes learning and memory impairments in the P301S mouse model of tauopathies and Alzheimer's disease
العنوان: | Accelerated sarcopenia precedes learning and memory impairments in the P301S mouse model of tauopathies and Alzheimer's disease |
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المؤلفون: | Savannah Longo, María Laura Messi, Zhong‐Min Wang, William Meeker, Osvaldo Delbono |
المصدر: | Journal of Cachexia, Sarcopenia and Muscle, Vol 15, Iss 4, Pp 1358-1375 (2024) |
بيانات النشر: | Wiley, 2024. |
سنة النشر: | 2024 |
المجموعة: | LCC:Diseases of the musculoskeletal system LCC:Human anatomy |
مصطلحات موضوعية: | Alzheimer's disease, Denervation, P301S tau mutation, PS19 mouse line, Sarcopenia, Skeletal muscle, Diseases of the musculoskeletal system, RC925-935, Human anatomy, QM1-695 |
الوصف: | Abstract Background Alzheimer's disease (AD) impairs cognitive functions and peripheral systems, including skeletal muscles. The PS19 mouse, expressing the human tau P301S mutation, shows cognitive and muscular pathologies, reflecting the central and peripheral atrophy seen in AD. Methods We analysed skeletal muscle morphology and neuromuscular junction (NMJ) through immunohistochemistry and advanced image quantification. A factorial Analysis of Variance assessed muscle weight, NCAM expression, NMJ, myofibre type distribution, cross‐sectional areas, expression of single or multiple myosin heavy‐chain isoforms, and myofibre grouping in PS19 and wild type (WT) mice over their lifespan (1–12 months). Results Significant weight differences in extensor digitorum longus (EDL) and soleus muscles between WT and PS19 mice were noted by 7–8 months. For EDL muscle in females, WT weighed 0.0113 ± 0.0005 compared with PS19's 0.0071 ± 0.0008 (P |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 2190-6009 2190-5991 |
Relation: | https://doaj.org/toc/2190-5991; https://doaj.org/toc/2190-6009 |
DOI: | 10.1002/jcsm.13482 |
URL الوصول: | https://doaj.org/article/dd672c9e72394b54810d892b99a2c3da |
رقم الأكسشن: | edsdoj.672c9e72394b54810d892b99a2c3da |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 21906009 21905991 |
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DOI: | 10.1002/jcsm.13482 |