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Accelerated sarcopenia precedes learning and memory impairments in the P301S mouse model of tauopathies and Alzheimer's disease

التفاصيل البيبلوغرافية
العنوان: Accelerated sarcopenia precedes learning and memory impairments in the P301S mouse model of tauopathies and Alzheimer's disease
المؤلفون: Savannah Longo, María Laura Messi, Zhong‐Min Wang, William Meeker, Osvaldo Delbono
المصدر: Journal of Cachexia, Sarcopenia and Muscle, Vol 15, Iss 4, Pp 1358-1375 (2024)
بيانات النشر: Wiley, 2024.
سنة النشر: 2024
المجموعة: LCC:Diseases of the musculoskeletal system
LCC:Human anatomy
مصطلحات موضوعية: Alzheimer's disease, Denervation, P301S tau mutation, PS19 mouse line, Sarcopenia, Skeletal muscle, Diseases of the musculoskeletal system, RC925-935, Human anatomy, QM1-695
الوصف: Abstract Background Alzheimer's disease (AD) impairs cognitive functions and peripheral systems, including skeletal muscles. The PS19 mouse, expressing the human tau P301S mutation, shows cognitive and muscular pathologies, reflecting the central and peripheral atrophy seen in AD. Methods We analysed skeletal muscle morphology and neuromuscular junction (NMJ) through immunohistochemistry and advanced image quantification. A factorial Analysis of Variance assessed muscle weight, NCAM expression, NMJ, myofibre type distribution, cross‐sectional areas, expression of single or multiple myosin heavy‐chain isoforms, and myofibre grouping in PS19 and wild type (WT) mice over their lifespan (1–12 months). Results Significant weight differences in extensor digitorum longus (EDL) and soleus muscles between WT and PS19 mice were noted by 7–8 months. For EDL muscle in females, WT weighed 0.0113 ± 0.0005 compared with PS19's 0.0071 ± 0.0008 (P
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2190-6009
2190-5991
Relation: https://doaj.org/toc/2190-5991; https://doaj.org/toc/2190-6009
DOI: 10.1002/jcsm.13482
URL الوصول: https://doaj.org/article/dd672c9e72394b54810d892b99a2c3da
رقم الأكسشن: edsdoj.672c9e72394b54810d892b99a2c3da
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:21906009
21905991
DOI:10.1002/jcsm.13482