Acquired resistance to combined BET and CDK4/6 inhibition in triple-negative breast cancer

التفاصيل البيبلوغرافية
العنوان:	Acquired resistance to combined BET and CDK4/6 inhibition in triple-negative breast cancer
المؤلفون:	Jennifer Y. Ge, Shaokun Shu, Mijung Kwon, Bojana Jovanović, Katherine Murphy, Anushree Gulvady, Anne Fassl, Anne Trinh, Yanan Kuang, Grace A. Heavey, Adrienne Luoma, Cloud Paweletz, Aaron R. Thorner, Kai W. Wucherpfennig, Jun Qi, Myles Brown, Piotr Sicinski, Thomas O. McDonald, David Pellman, Franziska Michor, Kornelia Polyak
المصدر:	Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
بيانات النشر:	Nature Portfolio, 2020.
سنة النشر:	2020
المجموعة:	LCC:Science
مصطلحات موضوعية:	Science
الوصف:	Effective combination therapies to improve the efficacy of BET inhibitors are currently under investigation. Here, the authors examine palbociclib and paclitaxel as two promising candidates for combination therapies with BET inhibition in breast cancer and investigate the dynamics of resistance to these combinations through DNA barcoding and mathematical modelling.
نوع الوثيقة:	article
وصف الملف:	electronic resource
اللغة:	English
تدمد:	2041-1723
Relation:	https://doaj.org/toc/2041-1723
DOI:	10.1038/s41467-020-16170-3
URL الوصول:	https://doaj.org/article/c6750e9707894301940edb49bbf81051
رقم الأكسشن:	edsdoj.6750e9707894301940edb49bbf81051
قاعدة البيانات:	Directory of Open Access Journals

الوصف
تدمد:	20411723
DOI:	10.1038/s41467-020-16170-3