دورية أكاديمية
A genome-wide association, polygenic risk score and sex study on opioid use disorder treatment outcomes
| العنوان: | A genome-wide association, polygenic risk score and sex study on opioid use disorder treatment outcomes |
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| المؤلفون: | Alannah McEvoy, Caroul Chawar, Amel Lamri, Jacqueline Hudson, Luciano Minuzzi, David C. Marsh, Lehana Thabane, Andrew D. Paterson, Zainab Samaan |
| المصدر: | Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023) |
| بيانات النشر: | Nature Portfolio, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | Abstract Opioid use disorder continues to be a health concern with a high rate of opioid related deaths occurring worldwide. Medication Assisted Treatments (MAT) have been shown to reduce opioid withdrawal, cravings and opioid use, however variability exists in individual’s treatment outcomes. Sex-specific differences have been reported in opioid use patterns, polysubstance use and health and social functioning. Candidate gene studies investigating methadone dose as an outcome have identified several candidate genes and only five genome-wide associations studies have been conducted for MAT outcomes. This study aimed to identify genetic variants associated with MAT outcomes through genome-wide association study (GWAS) and test the association between genetic variants previously associated with methadone dose through a polygenic risk score (PRS). Study outcomes include: continued opioid use, relapse, methadone dose and opioid overdose. No genome-wide significance SNPs or sex-specific results were identified. The PRS identified statistically significant results (p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-023-49605-0 |
| URL الوصول: | https://doaj.org/article/67ad56d376fb4475a75f2b513a7e85d6 |
| رقم الأكسشن: | edsdoj.67ad56d376fb4475a75f2b513a7e85d6 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-023-49605-0 |