دورية أكاديمية
Both Wnt signaling and epidermal stem cell-derived extracellular vesicles are involved in epidermal cell growth
| العنوان: | Both Wnt signaling and epidermal stem cell-derived extracellular vesicles are involved in epidermal cell growth |
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| المؤلفون: | Ling Leng, Jie Ma, Luye Lv, Wenjuan Wang, Dunqin Gao, Yunping Zhu, Zhihong Wu |
| المصدر: | Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-11 (2020) |
| بيانات النشر: | BMC, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Medicine (General) LCC:Biochemistry |
| مصطلحات موضوعية: | Epidermal stem cell, Extracellular vesicle, Organoids, Proteomics, Epidermal development, Extracellular matrix, Medicine (General), R5-920, Biochemistry, QD415-436 |
| الوصف: | Abstract Millions suffer from skin diseases. Functional interfollicular epidermal stem cells are needed in skin therapy or drug screening in vitro. We obtained functional interfollicular epidermal stem cells with intact stemness and cell junctions by treating them with Wnt3a. Moreover, epidermal stem cell-derived extracellular vesicles were useful in epidermal cell growth. Finally, functional epidermal 3D organoids with polarity were cultured using Wnt3a and the supernatant derived from interfollicular epidermal stem cells and fresh medium in a 1:1 ratio. These results provide novel directions for the improvement of skin organoids and their potential in clinical application. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1757-6512 |
| Relation: | http://link.springer.com/article/10.1186/s13287-020-01933-y; https://doaj.org/toc/1757-6512 |
| DOI: | 10.1186/s13287-020-01933-y |
| URL الوصول: | https://doaj.org/article/67ee60e875164e82a4e6cdf8dd9b5eea |
| رقم الأكسشن: | edsdoj.67ee60e875164e82a4e6cdf8dd9b5eea |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 17576512 |
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| DOI: | 10.1186/s13287-020-01933-y |