دورية أكاديمية
Impact of Tablet Size and Shape on the Swallowability in Older Adults
| العنوان: | Impact of Tablet Size and Shape on the Swallowability in Older Adults |
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| المؤلفون: | Henriette Hummler, Cordula Stillhart, Lisa Meilicke, Michael Grimm, Elischa Krause, Marwan Mannaa, Maik Gollasch, Werner Weitschies, Susanne Page |
| المصدر: | Pharmaceutics, Vol 15, Iss 4, p 1042 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Pharmacy and materia medica |
| مصطلحات موضوعية: | solid oral dosage forms, swallowability, medicine acceptability, preference, older adults, geriatric patients, Pharmacy and materia medica, RS1-441 |
| الوصف: | Older adults represent the major target population for oral medications, due to the high prevalence of multimorbidity. To allow for successful pharmacological treatments, patients need to adhere to their medication and, thus, patient-centric drug products with a high level of acceptability by the end users are needed. However, knowledge on the appropriate size and shape of solid oral dosage forms, as the most commonly used dosage forms in older adults, is still scarce. A randomized intervention study was performed including 52 older adults (65 to 94 years) and 52 young adults (19 to 36 years). Each participant swallowed four coated placebo tablets differing in weight (250 to 1000 mg) and shape (oval, round, oblong) in a blinded manner on three study days. The choice of tablet dimensions allowed for a systematic comparison between different tablet sizes of the same shape, as well as between different tablet shapes. Swallowability was assessed using a questionnaire-based method. All tested tablets were swallowed by ≥80% of adults, independent of age. However, only the 250 mg oval tablet was classified as well swallowable by ≥80% of old participants. The same was true for young participants; however, they also considered the 250 mg round and the 500 mg oval tablet as well swallowable. Furthermore, swallowability was seen to influence the willingness to take a tablet on a daily basis, especially for an intake over longer time periods. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 15041042 1999-4923 |
| Relation: | https://www.mdpi.com/1999-4923/15/4/1042; https://doaj.org/toc/1999-4923 |
| DOI: | 10.3390/pharmaceutics15041042 |
| URL الوصول: | https://doaj.org/article/6800ab65c3924a21907c3b03c99de86b |
| رقم الأكسشن: | edsdoj.6800ab65c3924a21907c3b03c99de86b |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 15041042 19994923 |
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| DOI: | 10.3390/pharmaceutics15041042 |