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Clinical management of heterozygous familial hypercholesterolemia in a Polish outpatient metabolic clinic: a retrospective observational study

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العنوان: Clinical management of heterozygous familial hypercholesterolemia in a Polish outpatient metabolic clinic: a retrospective observational study
المؤلفون: Longina Kłosiewicz-Latoszek, Barbara Cybulska, Janina Białobrzeska-Paluszkiewicz, Anna Jagielska, Jolanta Janowska, Dorota Danowska, Anna Reguła, Małgorzata Stroniawska-Woźniak
المصدر: Archives of Medical Science, Vol 14, Iss 5, Pp 962-970 (2017)
بيانات النشر: Termedia Publishing House, 2017.
سنة النشر: 2017
المجموعة: LCC:Medicine
مصطلحات موضوعية: familial hypercholesterolemia, outpatient clinic, lipid-lowering therapy, efficacy, Medicine
الوصف: Introduction : There are currently no reports available from a Polish clinical practice on heterozygous familial hypercholesterolemia (HeFH) management. The aim of this study was to test the efficacy of HeFH hypolipidemic treatment in a Polish outpatient metabolic clinic according to treatment targets outlined in the European Atherosclerosis Society (EAS) and European Society of Cardiology (ESC) guidelines. Material and methods : This retrospective, observational study was performed on HeFH patients who attended their routine follow-up visits in the metabolic outpatient clinic in the period between April and September 2016. According to EAS/ESC guidelines, the goal and intensity of therapy were assigned individually for every patient based on cardiovascular (CV) risk (high or very high). The treatment target was achievement of low-density lipoprotein cholesterol (LDL-C) levels < 1.8 mmol/l for very high CV risk patients and < 2.6 mmol/l for high CV risk patients. A ≥ 50% decrease in LDL-C over the observation period was an additional outcome measure. Results : In the overall group of 222 HeFH patients (mean age: 55.2 16.2 years, 72% women), LDL-C levels decreased on average by 52.6%. More than half of the patients were treated with the maximum tolerated dose of statins. A total of 25.2% of patients attained target levels of LDL-C and 55.9% attained a ≥ 50% reduction in its concentration. Despite therapy, significantly elevated post-follow-up levels of LDL-C (> 4.1 mmol/l) remained in 14% of all patients. Conclusions : Hypolipidemic therapy according to EAS/ESC guidelines was suboptimal for a significant number of HeFH patients. Additional clinical management should be considered.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1734-1922
1896-9151
Relation: https://www.termedia.pl/Clinical-management-of-heterozygous-familial-r-nhypercholesterolemia-in-a-Polish-outpatient-metabolic-r-nclinic-a-retrospective-observational-study,19,31181,1,1.html; https://doaj.org/toc/1734-1922; https://doaj.org/toc/1896-9151
DOI: 10.5114/aoms.2017.71855
URL الوصول: https://doaj.org/article/683accae2a7545918f752970da6291fb
رقم الأكسشن: edsdoj.683accae2a7545918f752970da6291fb
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:17341922
18969151
DOI:10.5114/aoms.2017.71855