دورية أكاديمية
Knockdown of the lncRNA SNHG8 inhibits cell growth in Epstein-Barr virus-associated gastric carcinoma
| العنوان: | Knockdown of the lncRNA SNHG8 inhibits cell growth in Epstein-Barr virus-associated gastric carcinoma |
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| المؤلفون: | Jing Liu, Chunxia Yang, Yufang Gu, Chong Li, Huamei Zhang, Wenfang Zhang, Xueqing Wang, Nan Wu, Chunyan Zheng |
| المصدر: | Cellular & Molecular Biology Letters, Vol 23, Iss 1, Pp 1-10 (2018) |
| بيانات النشر: | BMC, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Cytology |
| مصطلحات موضوعية: | SNHG8, Cell growth, shRNA, Epstein-Barr virus-associated gastric carcinoma, Cytology, QH573-671 |
| الوصف: | Abstract Background Epstein–Barr virus (EBV) infection is causatively associated with a variety of human cancers, including gastric cancer (GC), which has one of the highest mortality rates of all human cancers. Long non-coding RNAs (lncRNAs) show important regulatory roles in human GC. SNHG8 is a recently identified lncRNA that was reported to show abnormal expression pattern in GC. However, little is known of its biological function in EBV-associated GC. Methods We used cell viability, colony formation and cell cycle assays to investigate the roles of lncRNA SNHG8 in the cell growth of EBV-associated GC. Results The transcript levels of SNHG8 in the cultured EBV-associated GC cells were significantly higher in the cultured EBV-associated GC cells compared with the levels in normal human gastric mucosal cells and EBV-negative GC cells. Knockdown of SNHG8 with specific shRNAs inhibited cell proliferation and colony formation and arrested the cell cycle in the G0/G1 phase in vitro. We also found that knockdown of SNHG8 suppressed tumor growth in vivo. Conclusions These data indicate the pro-oncogenic potential of SNHG8 in EBV-associated GC, meaning it is a latent therapeutic target for the treatment of this type of cancer. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1425-8153 1689-1392 |
| Relation: | http://link.springer.com/article/10.1186/s11658-018-0070-8; https://doaj.org/toc/1425-8153; https://doaj.org/toc/1689-1392 |
| DOI: | 10.1186/s11658-018-0070-8 |
| URL الوصول: | https://doaj.org/article/ea6841178d244384837b67bc28dd62a4 |
| رقم الأكسشن: | edsdoj.6841178d244384837b67bc28dd62a4 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 14258153 16891392 |
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| DOI: | 10.1186/s11658-018-0070-8 |