دورية أكاديمية
m6A methylation in cellular senescence of age-associated diseases
| العنوان: | m6A methylation in cellular senescence of age-associated diseases |
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| المؤلفون: | Gao Pan, Yao Feng, Pang Jin, Yin Kai, Zhu Xiao |
| المصدر: | Acta Biochimica et Biophysica Sinica, Vol 55, Pp 1168-1183 (2023) |
| بيانات النشر: | China Science Publishing & Media Ltd., 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Biochemistry LCC:Genetics |
| مصطلحات موضوعية: | cellular senescence, N6-methyladenosine, age-associated diseases, Biochemistry, QD415-436, Genetics, QH426-470 |
| الوصف: | Cellular senescence is a state of irreversible cellular growth arrest that occurs in response to various stresses. In addition to exiting the cell cycle, senescent cells undergo many phenotypic alterations, including metabolic reprogramming, chromatin rearrangement, and senescence-associated secretory phenotype (SASP) development. Furthermore, senescent cells can affect most physiological and pathological processes, such as physiological development; tissue homeostasis; tumour regression; and age-associated disease progression, including diabetes, atherosclerosis, Alzheimer’s disease, and hypertension. Although corresponding anti-senescence therapies are actively being explored for the treatment of age-associated diseases, the specific regulatory mechanisms of senescence remain unclear. N6-methyladenosine (m6A), a chemical modification commonly distributed in eukaryotic RNA, plays an important role in biological processes such as translation, shearing, and RNA transcription. Numerous studies have shown that m6A plays an important regulatory role in cellular senescence and aging-related disease. In this review, we systematically summarize the role of m6A modifications in cellular senescence with regard to oxidative stress, DNA damage, telomere alterations, and SASP development. Additionally, diabetes, atherosclerosis, and Alzheimer’s disease regulation via m6A-mediated cellular senescence is discussed. We further discuss the challenges and prospects of m6A in cellular senescence and age-associated diseases with the aim of providing rational strategies for the treatment of these age-associated diseases. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1672-9145 |
| Relation: | https://doaj.org/toc/1672-9145 |
| DOI: | 10.3724/abbs.2023107 |
| URL الوصول: | https://doaj.org/article/c68719e58bb64b7486d108a2e647bfdc |
| رقم الأكسشن: | edsdoj.68719e58bb64b7486d108a2e647bfdc |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 16729145 |
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| DOI: | 10.3724/abbs.2023107 |