دورية أكاديمية
Conventional-Microwave Mediated Synthesis and In Vitro Antimicrobial Activity of Novel Carbazole-Efflux Pump Inhibitor Hybrid Antibacterials
| العنوان: | Conventional-Microwave Mediated Synthesis and In Vitro Antimicrobial Activity of Novel Carbazole-Efflux Pump Inhibitor Hybrid Antibacterials |
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| المؤلفون: | Ghazala Yaqub, Zubi Sadiq, Almas Hamid, Amber Fatima, Zainab Ijaz |
| المصدر: | Journal of Chemistry, Vol 2017 (2017) |
| بيانات النشر: | Wiley, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Chemistry |
| مصطلحات موضوعية: | Chemistry, QD1-999 |
| الوصف: | Work presented herein is the first report of two dual-action hybrids synthesized by covalent linkage of carbazole based novel antibacterial compounds with efflux pump inhibitors, that is, indole acetic acid/gallic acid. In this paper, novel antibacterial compounds 2 and 3 were prepared first and then these were covalently linked with efflux pump inhibitors, that is, indole acetic acid/gallic acid leading to the successful formation of two dual-action hybrids 4 and 5. Prepared antibacterials and hybrids were evaluated for their bacteria cell killing capability against Escherichia coli, Staphylococcus aureus, Pasteurella multocida, and Bacillus subtilis. Both antibacterial compounds 2 and 3 were found effective against all tested bacterial strains at different concentrations. But when these compounds were linked with efflux pump inhibitors, they showed dramatic enhancement in their bacterial cell killing potential and minimum inhibitory concentration of all hybrids ranging from 7.250 μg/mL to 0.05 μg/mL. These prepared hybrid drugs will be promising and effective new agents in the category of dual-action antibiotics. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2090-9063 2090-9071 |
| Relation: | https://doaj.org/toc/2090-9063; https://doaj.org/toc/2090-9071 |
| DOI: | 10.1155/2017/7243279 |
| URL الوصول: | https://doaj.org/article/d6876baa858c47fe81573e3aeeecbb1c |
| رقم الأكسشن: | edsdoj.6876baa858c47fe81573e3aeeecbb1c |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20909063 20909071 |
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| DOI: | 10.1155/2017/7243279 |