دورية أكاديمية
Molecular mechanisms of nanosized titanium dioxide-induced pulmonary injury in mice.
| العنوان: | Molecular mechanisms of nanosized titanium dioxide-induced pulmonary injury in mice. |
|---|---|
| المؤلفون: | Bing Li, Yuguan Ze, Qingqing Sun, Ting Zhang, Xuezi Sang, Yaling Cui, Xiaochun Wang, Suxin Gui, Danlin Tan, Min Zhu, Xiaoyang Zhao, Lei Sheng, Ling Wang, Fashui Hong, Meng Tang |
| المصدر: | PLoS ONE, Vol 8, Iss 2, p e55563 (2013) |
| بيانات النشر: | Public Library of Science (PLoS), 2013. |
| سنة النشر: | 2013 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | The pulmonary damage induced by nanosized titanium dioxide (nano-TiO2) is of great concern, but the mechanism of how this damage may be incurred has yet to be elucidated. Here, we examined how multiple genes may be affected by nano-TiO2 exposure to contribute to the observed damage. The results suggest that long-term exposure to nano-TiO2 led to significant increases in inflammatory cells, and levels of lactate dehydrogenase, alkaline phosphate, and total protein, and promoted production of reactive oxygen species and peroxidation of lipid, protein and DNA in mouse lung tissue. We also observed nano-TiO2 deposition in lung tissue via light and confocal Raman microscopy, which in turn led to severe pulmonary inflammation and pneumonocytic apoptosis in mice. Specifically, microarray analysis showed significant alterations in the expression of 847 genes in the nano-TiO2-exposed lung tissues. Of 521 genes with known functions, 361 were up-regulated and 160 down-regulated, which were associated with the immune/inflammatory responses, apoptosis, oxidative stress, the cell cycle, stress responses, cell proliferation, the cytoskeleton, signal transduction, and metabolic processes. Therefore, the application of nano-TiO2 should be carried out cautiously, especially in humans. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1932-6203 |
| Relation: | http://europepmc.org/articles/PMC3567101?pdf=render; https://doaj.org/toc/1932-6203 |
| DOI: | 10.1371/journal.pone.0055563 |
| URL الوصول: | https://doaj.org/article/a6892bc116844847acee356baff93fe9 |
| رقم الأكسشن: | edsdoj.6892bc116844847acee356baff93fe9 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19326203 |
|---|---|
| DOI: | 10.1371/journal.pone.0055563 |