دورية أكاديمية
The chicken frizzle feather is due to an α-keratin (KRT75) mutation that causes a defective rachis.
| العنوان: | The chicken frizzle feather is due to an α-keratin (KRT75) mutation that causes a defective rachis. |
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| المؤلفون: | Chen Siang Ng, Ping Wu, John Foley, Anne Foley, Merry-Lynn McDonald, Wen-Tau Juan, Chih-Jen Huang, Yu-Ting Lai, Wen-Sui Lo, Chih-Feng Chen, Suzanne M Leal, Huanmin Zhang, Randall B Widelitz, Pragna I Patel, Wen-Hsiung Li, Cheng-Ming Chuong |
| المصدر: | PLoS Genetics, Vol 8, Iss 7, p e1002748 (2012) |
| بيانات النشر: | Public Library of Science (PLoS), 2012. |
| سنة النشر: | 2012 |
| المجموعة: | LCC:Genetics |
| مصطلحات موضوعية: | Genetics, QH426-470 |
| الوصف: | Feathers have complex forms and are an excellent model to study the development and evolution of morphologies. Existing chicken feather mutants are especially useful for identifying genetic determinants of feather formation. This study focused on the gene F, underlying the frizzle feather trait that has a characteristic curled feather rachis and barbs in domestic chickens. Our developmental biology studies identified defects in feather medulla formation, and physical studies revealed that the frizzle feather curls in a stepwise manner. The frizzle gene is transmitted in an autosomal incomplete dominant mode. A whole-genome linkage scan of five pedigrees with 2678 SNPs revealed association of the frizzle locus with a keratin gene-enriched region within the linkage group E22C19W28_E50C23. Sequence analyses of the keratin gene cluster identified a 69 bp in-frame deletion in a conserved region of KRT75, an α-keratin gene. Retroviral-mediated expression of the mutated F cDNA in the wild-type rectrix qualitatively changed the bending of the rachis with some features of frizzle feathers including irregular kinks, severe bending near their distal ends, and substantially higher variations among samples in comparison to normal feathers. These results confirmed KRT75 as the F gene. This study demonstrates the potential of our approach for identifying genetic determinants of feather forms. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1553-7390 1553-7404 |
| Relation: | http://europepmc.org/articles/PMC3400578?pdf=render; https://doaj.org/toc/1553-7390; https://doaj.org/toc/1553-7404 |
| DOI: | 10.1371/journal.pgen.1002748 |
| URL الوصول: | https://doaj.org/article/68ec5c591c374e7b9c1b83cc27279b8e |
| رقم الأكسشن: | edsdoj.68ec5c591c374e7b9c1b83cc27279b8e |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 15537390 15537404 |
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| DOI: | 10.1371/journal.pgen.1002748 |