دورية أكاديمية
Synergistic effects of magnesium ions and simvastatin on attenuation of high-fat diet-induced bone loss
| العنوان: | Synergistic effects of magnesium ions and simvastatin on attenuation of high-fat diet-induced bone loss |
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| المؤلفون: | Bingyang Dai, Xu Li, Jiankun Xu, Yuwei Zhu, Le Huang, Wenxue Tong, Hao Yao, Dick Ho-kiu Chow, Ling Qin |
| المصدر: | Bioactive Materials, Vol 6, Iss 8, Pp 2511-2522 (2021) |
| بيانات النشر: | KeAi Communications Co., Ltd., 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Materials of engineering and construction. Mechanics of materials LCC:Biology (General) |
| مصطلحات موضوعية: | Obesity, Bone loss, Magnesium, Simvastatin, Trabecular bone, Cholesterol, Materials of engineering and construction. Mechanics of materials, TA401-492, Biology (General), QH301-705.5 |
| الوصف: | Introduction: Magnesium (Mg) has a prophylactic potential against the onset of hyperlipidemia. Similar to statin, Mg is recommended as lipid-lowering medication for hypercholesterolemia and concomitantly exhibits an association with increased bone mass. The combination of statin with Mg ions (Mg2+) may be able to alleviate the high-fat diet (HFD)-induced bone loss and reduce the side-effects of statin. This study aimed to explore the feasibility of combined Mg2+ with simvastatin (SIM) for treating HFD-induced bone loss in mice and the involving mechanisms. Materials and methods: C57BL/6 male mice were fed with a HFD or a normal-fat diet (NFD). Mice were intraperitoneally injected SIM and/or orally received water with additional Mg2+ until sacrificed. Enzyme-linked immunosorbent assay was performed to measure cytokines and cholesterol in serum and liver lysates. Bone mineral density (BMD) and microarchitecture were assessed by micro-computed tomography (μCT) in different groups. The adipogenesis in palmitate pre-treated HepG2 cells was performed under various treatments. Results: μCT analysis showed that the trabecular bone mass was significantly lower in the HFD-fed group than that in NFD-fed group since week 8. The cortical thickness in HFD-fed group had a significant decrease at week 24, as compared with NFD-fed group. The combination of Mg2+ and SIM significantly attenuated the trabecular bone loss in HFD-fed mice via arresting the osteoclast formation and bone resorption. Besides, such combination also reduced the hepatocytic synthesis of cholesterol and inhibited matrix metallopeptidase 13 (Mmp13) mRNA expression in pre-osteoclasts. Conclusions: The combination of Mg2+ and SIM shows a synergistic effect on attenuating the HFD-induced bone loss. Our current formulation may be a cost-effective alternative treatment to be indicated for obesity-related bone loss. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2452-199X |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2452199X21000396; https://doaj.org/toc/2452-199X |
| DOI: | 10.1016/j.bioactmat.2021.01.027 |
| URL الوصول: | https://doaj.org/article/6905910619dc43e6a72a5d58f87058aa |
| رقم الأكسشن: | edsdoj.6905910619dc43e6a72a5d58f87058aa |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2452199X |
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| DOI: | 10.1016/j.bioactmat.2021.01.027 |