دورية أكاديمية
The possible role of granzyme B in the pathogenesis of chronic obstructive pulmonary disease
| العنوان: | The possible role of granzyme B in the pathogenesis of chronic obstructive pulmonary disease |
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| المؤلفون: | David A. Ngan, Shawna V. Vickerman, David J. Granville, S. F. Paul Man, Don D. Sin |
| المصدر: | Therapeutic Advances in Respiratory Disease, Vol 3 (2009) |
| بيانات النشر: | SAGE Publishing, 2009. |
| سنة النشر: | 2009 |
| المجموعة: | LCC:Diseases of the respiratory system |
| مصطلحات موضوعية: | Diseases of the respiratory system, RC705-779 |
| الوصف: | Chronic obstructive pulmonary disease (COPD) is a highly prevalent inflammatory lung condition characterized by airways disease and emphysema, and the precise mechanism of pathogenesis is poorly understood. The consistent features of COPD include protease-antiprotease imbalance, inflammation and accelerated aging caused by apoptosis or senescence. One family of molecules involved in all of these processes is the granzymes, serine proteases with the best-known member being granzyme B (GzmB). The majority of GzmB is released unidirectionally towards target cells, but GzmB can also be released nonspecifically and escape into the extracellular environment. GzmB is capable of cleaving extracellular matrix (ECM) proteins in vitro , and the accumulation of GzmB in the extracellular milieu during chronic inflammation in COPD could contribute to ECM degradation and remodelling and, consequently, the emphysematous phenotype in the lung. Preliminary studies suggest that increased GzmB expression is associated with increased COPD severity, and this may represent a promising new target for drug and biomarker discovery in COPD. In this paper, we review the potential pathogenic contributions of GzmB to the pathogenesis of COPD. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1753-4658 17534658 |
| Relation: | https://doaj.org/toc/1753-4658 |
| DOI: | 10.1177/1753465809341965 |
| URL الوصول: | https://doaj.org/article/691242cc0e274fc4aef70e1761cd5c7a |
| رقم الأكسشن: | edsdoj.691242cc0e274fc4aef70e1761cd5c7a |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17534658 |
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| DOI: | 10.1177/1753465809341965 |