دورية أكاديمية
A Pilot Study of Immune Activation and Rifampin Absorption in HIV-Infected Patients without Tuberculosis Infection: A Short Report
| العنوان: | A Pilot Study of Immune Activation and Rifampin Absorption in HIV-Infected Patients without Tuberculosis Infection: A Short Report |
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| المؤلفون: | Christopher Vinnard, Isabel Manley, Brittney Scott, Mariana Bernui, Joella Adams, Sheryl Varghese, Isaac Zentner, Michele A. Kutzler |
| المصدر: | Tuberculosis Research and Treatment, Vol 2017 (2017) |
| بيانات النشر: | Wiley, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | Medicine |
| الوصف: | Background. Rifampin malabsorption is frequently observed in tuberculosis patients coinfected with human immunodeficiency virus (HIV) but cannot be predicted by patient factors such as CD4+ T cell count or HIV viral load. Methods. We sought to describe the relationship between HIV-associated immune activation, measures of gut absorptive capacity and permeability, and rifampin pharmacokinetic parameters in a pilot study of 6 HIV-infected, tuberculosis-uninfected patients who were naïve to antiretroviral therapy. Results. The median rifampin area under the concentration-versus-time curve during the 8-hour observation period was 42.8 mg·hr/L (range: 21.2 to 57.6), with a median peak concentration of 10.1 mg/L (range: 5.3 to 12.5). We observed delayed rifampin absorption, with a time to maximum concentration greater than 2 hours, in 2 of 6 participants. There was a trend towards increased plasma concentrations of sCD14, a marker of monocyte activation in response to bacterial translocation, among participants with delayed rifampin absorption compared to participants with rapid absorption (p=0.06). Conclusions. Delayed rifampin absorption may be associated with elevated markers of bacterial translocation among HIV-infected individuals naïve to antiretroviral therapy. This trial is registered with NCT01845298. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2090-150X 2090-1518 |
| Relation: | https://doaj.org/toc/2090-150X; https://doaj.org/toc/2090-1518 |
| DOI: | 10.1155/2017/2140974 |
| URL الوصول: | https://doaj.org/article/69a8158ccad64e999e370a2c56479ad6 |
| رقم الأكسشن: | edsdoj.69a8158ccad64e999e370a2c56479ad6 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2090150X 20901518 |
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| DOI: | 10.1155/2017/2140974 |