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Redox imbalance induced by docetaxel in the neuroblastoma SH-SY5Y cells: a study of docetaxel-induced neuronal damage

التفاصيل البيبلوغرافية
العنوان: Redox imbalance induced by docetaxel in the neuroblastoma SH-SY5Y cells: a study of docetaxel-induced neuronal damage
المؤلفون: Lucia Micheli, Giulia Collodel, Elena Moretti, Daria Noto, Andrea Menchiari, Daniela Cerretani, Sergio Crispino, Cinzia Signorini
المصدر: Redox Report, Vol 26, Iss 1, Pp 18-28 (2021)
بيانات النشر: Taylor & Francis Group, 2021.
سنة النشر: 2021
المجموعة: LCC:Pathology
LCC:Biology (General)
مصطلحات موضوعية: apoptosis, cellular antioxidants, chemobrain, docetaxel, isoprostanes, sh-sy5y cells, tubulin, transmission electron microscopy, Pathology, RB1-214, Biology (General), QH301-705.5
الوصف: Objectives In cancer survivors, chemotherapy-associated adverse neurological effects are described as side effects in non-targeted tissue. We investigated the role of redox-imbalance in neuronal damage by a relative low dose of Docetaxel (DTX). Methods The neuroblastoma cells (SH-SY5Y cells) were exposed to DTX at a dose of 1.25 nM for 6 h. Antioxidant defenses (i.e. ascorbic acid, glutathione, and catalase) and lipid oxidation products (i.e. F2-isoprostanes) were evaluated. To investigate cell ultrastructure and tubulin localisation, transmission electron microscopy (TEM) and immunofluorescence techniques were applied. Results In the SH-SY5Y cells, DTX induced a significant reduction of total glutathione (P
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1351-0002
1743-2928
13510002
Relation: https://doaj.org/toc/1351-0002; https://doaj.org/toc/1743-2928
DOI: 10.1080/13510002.2021.1884802
URL الوصول: https://doaj.org/article/69b5ffd6a1384a16bb4f7880b5dd2293
رقم الأكسشن: edsdoj.69b5ffd6a1384a16bb4f7880b5dd2293
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:13510002
17432928
DOI:10.1080/13510002.2021.1884802