دورية أكاديمية
Effect of Biospray Dressings on Eosinophil Infiltration in the Nasal Mucosa and Serum IgE Levels After Nasal Provocation in Experimental Allergic Rhinitis
| العنوان: | Effect of Biospray Dressings on Eosinophil Infiltration in the Nasal Mucosa and Serum IgE Levels After Nasal Provocation in Experimental Allergic Rhinitis |
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| المؤلفون: | Shan Huang BSc, Geping Wu MD, PhD, Xiaodan Gu BSM, Hongyan Zhu MD, Xingkai Ma BSM, Yifang Yuan BSM, Yan Lv MD, Di Li MD, Ling Zhang MD |
| المصدر: | Allergy & Rhinology, Vol 11 (2020) |
| بيانات النشر: | SAGE Publishing, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Otorhinolaryngology LCC:Immunologic diseases. Allergy |
| مصطلحات موضوعية: | Otorhinolaryngology, RF1-547, Immunologic diseases. Allergy, RC581-607 |
| الوصف: | Purpose To investigate the effect of biospray dressing on the extent of eosinophil infiltration in the nasal mucosa and the level of serum IgE in experimental allergic rhinitis with nasal provocation. Method Twenty-four BALB/c mice were randomly divided into the normal control group, allergic rhinitis (AR) group, dexamethasone (DEX) treatment group, and biospray dressing (BD) group. The mice in the latter 3 groups were prepared for animal models of AR according to standard protocols. Mice in the BD group were administered a nasal spray before the nasal provocation, and those in the DEX group were administered an intraperitoneal injection of DEX. The nasal mucosa and serum were collected from each group. Nasal mucosa eosinophil infiltration was evaluated using hematoxylin and eosin staining, and enzyme-linked immunosorbent assay (ELISA) was performed to analyze the serum IgE expression. Results Eosinophil infiltration (AR vs BD P = .009) in the nasal mucosa and serum IgE expression (AR vs BD P = .001) were significantly lower in the BD group than in the AR group. There were no significant differences in the extent of eosinophil infiltration in the nasal mucosa or serum IgE expression between the BD and DEX groups. Conclusion Biospray dressings can significantly reduce allergen provocation in the nasal cavity and have a protective effect on the nasal mucosa. They can be used for the prevention and treatment of AR. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2152-6567 21526567 |
| Relation: | https://doaj.org/toc/2152-6567 |
| DOI: | 10.1177/2152656720902142 |
| URL الوصول: | https://doaj.org/article/d69c884f3a7647729456730c40366d53 |
| رقم الأكسشن: | edsdoj.69c884f3a7647729456730c40366d53 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 21526567 |
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| DOI: | 10.1177/2152656720902142 |