دورية أكاديمية
Precise Tuning of Polymeric Fiber Dimensions to Enhance the Mechanical Properties of Alginate Hydrogel Matrices
| العنوان: | Precise Tuning of Polymeric Fiber Dimensions to Enhance the Mechanical Properties of Alginate Hydrogel Matrices |
|---|---|
| المؤلفون: | Zehua Li, Amanda K. Pearce, Andrew P. Dove, Rachel K. O’Reilly |
| المصدر: | Polymers, Vol 13, Iss 13, p 2202 (2021) |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Organic chemistry |
| مصطلحات موضوعية: | crystallization-driven self-assembly, calcium alginate hydrogel, cylindrical micelles, Organic chemistry, QD241-441 |
| الوصف: | Hydrogels based on biopolymers, such as alginate, are commonly used as scaffolds in tissue engineering applications as they mimic the features of the native extracellular matrix (ECM). However, in their native state, they suffer from drawbacks including poor mechanical performance and a lack of biological functionalities. Herein, we have exploited a crystallization-driven self-assembly (CDSA) methodology to prepare well-defined one-dimensional micellar structures with controlled lengths to act as a mimic of fibrillar collagen in native ECM and improve the mechanical strength of alginate-based hydrogels. Poly(ε-caprolactone)-b-poly(methyl methacrylate)-b-poly(N, N-dimethyl acrylamide) triblock copolymers were self-assembled into 1D cylindrical micelles with precise lengths using CDSA epitaxial growth and subsequently combined with calcium alginate hydrogel networks to obtain nanocomposites. Rheological characterization determined that the inclusion of the cylindrical structures within the hydrogel network increased the strength of the hydrogel under shear. Furthermore, the strain at flow point of the alginate-based hydrogel was found to increase with nanoparticle content, reaching an improvement of 37% when loaded with 500 nm cylindrical micelles. Overall, this study has demonstrated that one-dimensional cylindrical nanoparticles with controlled lengths formed through CDSA are promising fibrillar collagen mimics to build ECM scaffold models, allowing exploration of the relationship between collagen fiber size and matrix mechanical properties. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 13132202 2073-4360 |
| Relation: | https://www.mdpi.com/2073-4360/13/13/2202; https://doaj.org/toc/2073-4360 |
| DOI: | 10.3390/polym13132202 |
| URL الوصول: | https://doaj.org/article/69d567a39f354645b8e4f93fafbde774 |
| رقم الأكسشن: | edsdoj.69d567a39f354645b8e4f93fafbde774 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 13132202 20734360 |
|---|---|
| DOI: | 10.3390/polym13132202 |