دورية أكاديمية
أعرض في EDS

Practical Applicability of the ISARIC-4C Score on Severity and Mortality due to SARS-CoV-2 Infection in Patients with Type 2 Diabetes

التفاصيل البيبلوغرافية
العنوان: Practical Applicability of the ISARIC-4C Score on Severity and Mortality due to SARS-CoV-2 Infection in Patients with Type 2 Diabetes
المؤلفون: Oana Albai, Mirela Frandes, Alexandra Sima, Bogdan Timar, Adrian Vlad, Romulus Timar
المصدر: Medicina, Vol 58, Iss 7, p 848 (2022)
بيانات النشر: MDPI AG, 2022.
سنة النشر: 2022
المجموعة: LCC:Medicine (General)
مصطلحات موضوعية: SARS-CoV-2 infection, ISARIC-4C score, diabetes mellitus, risk, severity, mortality, Medicine (General), R5-920
الوصف: Background and objectives. There is a bidirectional relationship between SARS-CoV-2 infection and diabetes mellitus (DM), as people with DM are more vulnerable, and SARS-CoV-2 infections worsen the prognosis in these patients. The main purpose of the study was to evaluate the application validity of the ISARIC-4C score in patients confirmed with SARS-CoV-2 infection. Materials and Methods. The study included 159 patients previously known to have type 2 DM and confirmed positive for SARS-CoV-2 infection. We analyzed the concordance between the clinical evaluation of the patients and the ISARIC-4C score. Results. The mortality rate in hospitalized patients was 25.15%. The mortality risk was higher for ISARIC-4C values >14 than in the opposite group (63.93% vs. 31.24%; p < 0.001). The area under the curve (AUC) of the mortality score was 0.875 (95% CI: 0.820–0.930; p < 0.001), correctly classifying 77.36% of the cohort. A cut-off value of >14 had a sensitivity of 87.80% (95% CI: 87.66–87.93), specificity 73.72% (95% CI: 73.48–73.96), positive predictive value 53.73% (95% CI: 53.41–54.04), and negative predictive value 94.56% (95% CI: 94.5–94.62). The Cox regression model showed that the length of hospitalization (LH) was significantly influenced by body mass index, lung impairment, and aspartate aminotransferase, increasing the hazards, while lower HbA1c and lower SatO2 significantly decreased the hazards. Conclusions. ISARIC-4C score estimates the likelihood of clinical deterioration and the mortality risk in patients hospitalized with type 2 DM and positive for SARS-CoV-2, being useful in assessing the prognosis from the onset, as well as in developing therapeutic strategies.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1648-9144
1010-660X
Relation: https://www.mdpi.com/1648-9144/58/7/848; https://doaj.org/toc/1010-660X; https://doaj.org/toc/1648-9144
DOI: 10.3390/medicina58070848
URL الوصول: https://doaj.org/article/a69f53d0d48a4014976a0e56d63540b6
رقم الأكسشن: edsdoj.69f53d0d48a4014976a0e56d63540b6
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:16489144
1010660X
DOI:10.3390/medicina58070848